914220-85-2 Usage
Uses
Used in Organic Synthesis:
N-methoxy-N-methyl-2-oxopropanamide is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the formation of desired products in the synthesis of complex organic molecules.
Used as a Protecting Group in Peptide Synthesis:
In the pharmaceutical and biotechnological industries, N-methoxy-N-methyl-2-oxopropanamide is utilized as a protecting group for amines. This application is crucial for preventing unwanted side reactions during the assembly of peptide chains, ensuring the accurate formation of peptide bonds and the synthesis of the desired peptide sequence.
Used as a Mild Base in Organic Reactions:
N-methoxy-N-methyl-2-oxopropanamide serves the function of a mild base in certain organic reactions, aiding in the deprotonation of acidic protons without causing excessive side reactions or decomposition of reactants, which is particularly valuable in sensitive synthetic processes.
Used as a Solvent in Chemical Processes:
In specific chemical procedures, N-methoxy-N-methyl-2-oxopropanamide is employed as a solvent. Its solvent properties are advantageous for dissolving a variety of substances and facilitating the desired chemical transformations.
Safety Considerations:
While N-methoxy-N-methyl-2-oxopropanamide is considered to have low toxicity, it is essential to adhere to safety protocols when handling this chemical compound in laboratory environments to minimize potential health and environmental risks.
Check Digit Verification of cas no
The CAS Registry Mumber 914220-85-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,2,2 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 914220-85:
(8*9)+(7*1)+(6*4)+(5*2)+(4*2)+(3*0)+(2*8)+(1*5)=142
142 % 10 = 2
So 914220-85-2 is a valid CAS Registry Number.
914220-85-2Relevant academic research and scientific papers
Ru-catalyzed highly enantioselective hydrogenation of α-keto Weinreb amides
Zhao, Meng Meng,Li, Wan Fang,Ma, Xin,Fan, Wei Zheng,Tao, Xiao Ming,Li, Xiao Ming,Xie, Xiao Min,Zhang, Zhao Guo
, p. 342 - 348 (2013/07/26)
Asymmetric hydrogenation of α-keto Weinreb amides has been realized with [Ru((S)-Sunphos)(benzene)Cl]Cl as the catalyst and CeCl3· 7H2O as the additive. A series of enantiopure α-hydroxy Weinreb amides (up to 97% ee) have been obtained. Catalytic amount of CeCl 3·7H2O is essential for the high reactivity and enantioselectivity and the ratio of CeCl3·7H2O to [Ru((S)-Sunphos)(benzene)Cl]Cl plays an important role in the hydrogenation reaction.
New methodology for the synthesis of α,α-difluoroketones
Biju, Purakkattle
, p. 1940 - 1945 (2008/09/20)
A new methodology is described for the synthesis of α,α- difluorinated ketones by the addition of organolithium reagents to α,α-difluoro-N-methoxy-N-methyl amides (Weinreb amides). Copyright Taylor & Francis Group, LLC.
