914299-79-9

Basic information

• Product Name: (S)-3-phenylmorpholine
• Synonyms: (S)-3-phenylmorpholine;Morpholine, 3-phenyl-, (3S)-;(3S)-3-phenylmorpholine
• CAS NO: 914299-79-9
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.2
• Mol File: 914299-79-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 272°C at 760 mmHg
• Flash Point: 104.9°C
• Appearance: /
• Density: 1.034g/cm³
• Vapor Pressure: 0.00623mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: (S)-3-phenylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-phenylmorpholine(914299-79-9)
• EPA Substance Registry System: (S)-3-phenylmorpholine(914299-79-9)

Safety Data

• Hazardous Substances Data: 914299-79-9(Hazardous Substances Data)

Usage

General Description

(S)-3-phenylmorpholine is a chemical compound that belongs to the class of morpholine derivatives. It is an enantiomer of 3-phenylmorpholine and is known for its use in various chemical reactions and drug synthesis. (S)-3-phenylmorpholine is a colorless liquid with a molecular formula of C11H15NO and a molecular weight of 177.24 g/mol. It has potential applications in the pharmaceutical industry as a building block for the synthesis of various bioactive compounds and pharmaceutical drugs. Additionally, (S)-3-phenylmorpholine may also be used as a chiral ligand in asymmetric catalysis. Overall, this chemical compound has important implications in organic chemistry and pharmaceutical research.

InChI:InChI=1/C10H13NO/c1-2-4-9(5-3-1)10-8-12-7-6-11-10/h1-5,10-11H,6-8H2/t10-/m1/s1

Upstream product

• 20989-17-7 (2S)-2-phenylglycinol 
• 291545-74-9 (S)-2-chloro-N-(2-hydroxyl-1-phenylethyl)acetamide 
• 79-04-9 chloroacetyl chloride 
• 529-20-4 2-methylphenyl aldehyde 
• 1544430-88-7 (3S)-3-phenyl-4-(para-toluenesulfonyl)morpholine 
• 108-95-2 phenol 
• 1052209-96-7 (S)-5-phenylmorpholin-3-one 

Downstream Products

• 1052208-78-2 C₁₉H₂₂N₂O₂S 
• 1544431-59-5 (3S)-3-phenyl-N-methylmorpholine 

Relevant articles and documents

Using the competing enantioselective conversion method to assign the absolute configuration of cyclic amines with BODE’s acylation reagents

The competing enantioselective conversion (CEC) method is a quick and reliable means to determine absolute configuration. Previously, Bode’s chiral acylated hydroxamic acids were used to determine the stereochemistry of primary amines, as well as cyclic and acyclic secondary amines. The enantioselective acylation has been evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally relevant compounds. The limitations of the method were studied through computational analysis and experimental results. Piperidines with substituents at the 2-position did not behave well unless the axial conformer was energetically accessible, which is consistent with the transition state geometries proposed by Bode and Kozlowski. Control experiments were performed to investigate the cause of degrading selectivity under the CEC reaction conditions. The present study expands the scope of the CEC method for secondary amines and provides a better understanding of the reaction profile.

Aminoheteroaryl benzamides as kinase inhibitors

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Tertiary amine-promoted enone aziridination: Investigations into factors influencing enantioselective induction

trans-N-Unsubstituted aziridines were synthesised (up to 77% ee) via a chiral tertiary amine-promoted nucleophilic aziridination of a,b-unsaturated ketones utilising in situ generated N-N ylides (aminimines). A wide range of chiral tertiary amines were sy