91444-55-2

Upstream product

• 64-19-7 acetic acid 
• 91444-54-1 2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol 
• 75-36-5 acetyl chloride 
• 25743-57-1 1-(4-acetoxy-phenyl)-2-bromo-propan-1-one 
• 2623-33-8 4-acetoxyacetanilide 
• 91444-18-7 5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole 
• 21086-33-9 2-bromo-1-(4-methoxyphenyl)-1-propanone 
• 108-24-7 acetic anhydride 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 198481-32-2 bazedoxifene 

Relevant academic research and scientific papers

METHODS OF PREPARING　BAZOEDOXIFENE

The present invention relates to novel bazedoxifene or to a method for producing a pharmaceutically acceptable salt thereof. The production method according to the present invention can provide the bazedoxifene with high purity and high yield, and is economical and environmentally friendly in terms of time and cost due to a relatively simple manufacturing process to be usefully applied to mass production.COPYRIGHT KIPO 2018

Acetic acid [...] and intermediate preparation method

The invention discloses a bazedoxifene acetate intermediate and a preparation method thereof. The invention also discloses a method for preparing bazedoxifene acetate from the bazedoxifene acetate intermediate. The invention provides a method for preparing a novel intermediate of bazedoxifene acetate key as shown in the formula (II), the intermediate employs C1-6 alkyl acyl as protective group, and the method for preparing bazedoxifene acetate using the intermediate has the following advantages: (1) high pressure hydrogenation reaction with high risk for deprotection according to the traditional method (using benzyl as a protective group for protecting phenolic group) is avoided, and thereby greatly reducing danger of the experiment; 2. the reaction time is reduced and the industrial energy consumption is reduced; 3. the reaction of the present invention does not need palladium 10% on carbon; the preparation method is environmental friendly, and is suitable for industrial production, and has the advantages of mild condition and operation convenience.

2-Phenylindoles. Relationship between Structure, Estrogen Receptor Affinity, and Mammary Tumor Inhibiting Activity in the Rat

A number of 2-phenylindole derivatives with one hydroxy group in the meta or para position of the phenyl ring and a second one in position 5, 6, or 7 of the indole nucleus were synthesized.In addition, different alkyl groups were introduced into positions