914488-12-3

Upstream product

• 914382-64-2 (S)-2-tert-butoxycarbonylamino-4-hydroxy-butyric acid cyclopentyl ester 
• 914490-16-7 N-[4-(3-cyano-7-hydroxy-6-methoxy-quinolin-4-ylamino)-phenyl]-benzamide 
• 214476-99-0 7-benzyloxy-4-chloro-6-methoxyquinoline-3-carbonitrile 
• 914382-63-1 (S)-2-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid cyclopentyl ester 
• 214476-89-8 7-benzyloxy-6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carbonitrile 
• 914490-09-8 (E)-3-(3-benzyloxy-4-methoxy-phenylamino)-2-cyano-acrylic acid ethyl ester 
• 914490-14-5 N-[4-(7-benzyloxy-3-cyano-6-methoxy-quinolin-4-ylamino)-phenyl]-benzamide 
• 17625-83-1 N-(4-aminophenyl)benzamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 636-93-1 5-nitroguaiacol 
• 61324-40-1 3-benzyloxy-4-methoxybenzeneamine 
• 75167-86-1 2-(benzyloxy)-1-methoxy-4-nitrobenzene 
• 98-88-4 benzoyl chloride 
• 191655-45-5 (2S)‐2‐{[(tert‐butoxy)carbonyl]amino}‐4‐[(tert‐butyldimethylsilyl)oxy]butanoic acid 

Relevant academic research and scientific papers

QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY

Compounds of formula (IA) or (IB), are inhibitors of aurora kinase activity: Formula (IA), (IB) wherein -L1Y1-[CH2]z- is a linker radical wherein Y1, L1 and z are as defined in the claims; R6 is C1-C4alkoxy, hydrogen or halo; W represents a bond, -CH2-, -O-, -S-, -S(=O)2-, or -NR5- where R5 is hydrogen or C1-C4 alkyl; Q is =N-, =CH- or =C(X1)- wherein X1 is cyano, cyclopropyl or halo; linker radicals L2 are as defined in the claims; R is a radical of formula (X) or (Y): wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroaryl(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and D is a monocyclic heterocyclic ring of 5 or 6 ring atoms.