13024-49-2Relevant academic research and scientific papers
Probing Peripheral H-Bonding Functionalities in BN-Doped Polycyclic Aromatic Hydrocarbons
Tasseroul, Jonathan,Lorenzo-Garcia, Maria Mercedes,Dosso, Jacopo,Simon, Fran?ois,Velari, Simone,De Vita, Alessandro,Tecilla, Paolo,Bonifazi, Davide
, p. 3454 - 3464 (2020)
The replacement of carbon atoms at the zigzag periphery of a benzo[fg]tetracenyl derivative with an NBN atomic triad allows the formation of heteroatom-doped polycyclic aromatic hydrocarbon (PAH) isosteres, which expose BN mimics of the amidic NH function
Ultra-low-loading palladium nanoparticles stabilized on nanocrystalline Polyaniline (Pd@PANI): A efficient, green, and recyclable catalyst for the reduction of nitroarenes
Wang, Gang,Yuan, Shuo,Wu, Zhiqiang,Liu, Wanyi,Zhan, Haijuan,Liang, Yanping,Chen, Xiaoyan,Ma, Baojun,Bi, Shuxian
, (2019/08/30)
Ultra-low-loading Pd@PANI nanocomposites (0.048 w.t% Pd) were synthesized via a method that combined interfacial polymerization and in situ composite with camphor sulfonic acid ((+)-CSA) as a dopant. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectra, and X-ray photoelectron spectroscopy (XPS) were performed to characterize the structures. It can be used as an efficient catalyst for the reduction of nitroarenes in aqueous solution by using a smaller amount of NaBH4 (2.5 equiv.) at room temperature with high activity (TON?=?3.4?×?103), good stability (cycled eight times), as well as wide applicability (27 substrates). The catalyst also showed a marvelous activity in the gram-level reaction (yield?=?92%). UV–Visible spectrophotometry was used to investigate the reaction kinetics for the reduction of 4-nitrophenol to 4-aminophenol, and the results reconfirmed the excellent performance of the catalyst. The unique properties and superior performance of the prepared ultra-low-loading Pd@PANI nanocomposites lead it be an attractive alternative catalyst for conventional organic catalytic applications.
Development of a Unique Heterogeneous Palladium Catalyst for the Suzuki–Miyaura Reaction using (Hetero)aryl Chlorides and Chemoselective Hydrogenation
Ichikawa, Tomohiro,Netsu, Moeko,Mizuno, Masahiro,Mizusaki, Tomoteru,Takagi, Yukio,Sawama, Yoshinari,Monguchi, Yasunari,Sajiki, Hironao
supporting information, p. 2269 - 2279 (2017/07/07)
A unique heterogeneous palladium catalyst (7% Pd/WA30) supported on an anion exchange resin, which contains N,N-dimethylaminoalkyl functionalities on the polymer backbone, was developed. 7% Pd/WA30 could smoothly catalyze Suzuki–Miyaura reactions of even less reactive heteroaryl chlorides and heteroarylboronic acids to afford various (hetero)biaryls due to the electron-donating effect of the tert-amines on WA30 to Pd species. It was also applicable as a chemoselective hydrogenation catalyst, showing inactivity for the hydrogenolysis of tert-butyldimethylsilyl (TBS) ethers, alkyl benzyl ethers, and benzyl alcohols. The tert-amines on WA30 acted as moderate catalyst poisons for Pd, resulting in chemoselective hydrogenation. 7% Pd/WA30 was reused for at least five times without any loss of the hydrogenation catalytic activity. (Figure presented.).
Catalytic asymmetric hydrogenation using a [2.2]paracyclophane based chiral 1,2,3-triazol-5-ylidene-Pd complex under ambient conditions and 1 atmosphere of H2
Dasgupta, Ayan,Ramkumar, Venkatachalam,Sankararaman, Sethuraman
, p. 21558 - 21561 (2015/03/30)
Chiral 1,2,3-triazol-5-ylidene-Pd complexes with the planar chiral [2.2]paracyclophane wing tip group have been synthesized and structurally characterized. The complex with a labile acetonitrile co-ligand is an excellent catalyst for chemoselective hydrogenation of alkynes and alkenes and enantioselective hydrogenation of prochiral alkenes at ambient conditions and 1.0 atmosphere of H2.
Opioid peptidomimetics: Leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands
Mosberg, Henry I.,Yeomans, Larisa,Harland, Aubrie A.,Bender, Aaron M.,Sobczyk-Kojiro, Katarzyna,Anand, Jessica P.,Clark, Mary J.,Jutkiewicz, Emily M.,Traynor, John R.
, p. 2139 - 2149 (2013/05/08)
We have previously described opioid peptidomimetic, 1, employing a tetrahydroquinoline scaffold and modeled on a series of cyclic tetrapeptide opioid agonists. We have recently described modifications to these peptides that confer a μ opioid receptor (MOR) agonist, δ opioid receptor (DOR) antagonist profile, which has been shown to reduce the development of tolerance to the analgesic actions of MOR agonists. Several such bifunctional ligands have been reported, but none has been demonstrated to cross the blood-brain barrier. Here we describe the transfer of structural features that evoked MOR agonist/DOR antagonist behavior in the cyclic peptides to the tetrahydroquinoline scaffold and show that the resulting peptidomimetics maintain the desired pharmacological profile. Further, the 4R diastereomer of 1 was fully efficacious and approximately equipotent to morphine in the mouse warm water tail withdrawal assay following intraperitoneal administration and thus a promising lead for the development of opioid analgesics with reduced tolerance.
CLASS II HMG-COA REDUCTASE INHIBITORS AND METHODS OF USE
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Paragraph 0050, (2014/01/08)
Disclosed are compositions and methods for treating bacterial infections.
Palladium nanoparticles in glycerol: A versatile catalytic system for C-X bond formation and hydrogenation processes
Chahdoura, Faouzi,Pradel, Christian,Gomez, Montserrat
, p. 3648 - 3660 (2014/01/06)
Palladium nanoparticles stabilised by tris(3-sulfophenyl)phosphine trisodium salt in neat glycerol have been synthesised and fully characterised, starting from both Pd(II) and Pd(0) species. The versatility of this innovative catalytic colloidal solution has been proved by its efficient application in C-X bond formation processes (X=C, N, P, S) and C-C multiple bond hydrogenation reactions. The catalytic glycerol phase could be recycled more than ten times, preserving its activity and selectivity. The scope of each of these processes has demonstrated the power of the as-prepared catalyst, isolating the corresponding expected products in yields higher than 90%. The dual catalytic behaviour of this glycerol phase, associated to the metallic nanocatalysts used in wet medium (molecular- and surface-like behaviour), has allowed attractive applications in one-pot multi-step transformations catalysed by palladium, such as C-C coupling followed by hydrogenation, without isolation of intermediates using only one catalytic precursor. Copyright
Al-containing mesoporous carbon as effective catalysts for the chemoselective reduction of carbon-carbon double bonds in nitrostilbene derivatives
Wang, Liuchang,Zheng, Yanjun,Zhang, Xiquan,Gu, Hongmei,Li, Jiang,Wang, Wei,Li, Baolin
, p. 23 - 29 (2013/06/26)
A series of Al, Mn, Cu and Fe metal-containing mesoporous carbon catalysts were synthesized for catalyzing selective reduction of carbon-carbon double bond in 4-nitrostilbene analogs bearing nitro group with hydrazine hydrate. The results indicated that the reduction reaction was able to be achieved successfully between carbon-carbon double bond and nitro group. The efficient method has been developed for the reduction of CC double bonds with diimide, catalytically generated in situ from hydrazine hydrate by the synthesized catalysts. The 0.15Al-MC1 as heterogeneous catalyst exhibited the highest catalysis activity and chemoselectivity in all synthesized catalysts. In the presence of 0.15Al-MC1, the reduction of carbon-carbon double bond in 4-nitrostilbene derivatives was up to 99% yield and >99% chemoselectivity at 70 °C in ethanol. On the other hand, the high selective reduction of nitro group in 4-nitrostilbenes was also facile to be achieved with hydrazine hydrate, active carbon and FeCl3·6H2O under inert atmosphere.
Palladium on carbon-catalyzed solvent-free and solid-phase hydrogenation and Suzuki-Miyaura reaction
Monguchi, Yasunari,Fujita, Yuki,Hashimoto, Shota,Ina, Mariko,Takahashi, Tohru,Ito, Ryo,Nozaki, Kei,Maegawa, Tomohiro,Sajiki, Hironao
experimental part, p. 8628 - 8634 (2011/11/30)
The solvent-free and solid-phase hydrogenation of various reducible functionalities was efficiently catalyzed by heterogeneous palladium on carbon (Pd/C) under ambient hydrogen pressure and temperature. The Pd/C-catalyzed Suzuki-Miyaura coupling reaction between solid aryl bromides and solid arylboronic acids to generate the corresponding solid biaryls was also achieved under the totally solid-phase conditions.
Palladium nanoparticle-cored G1-dendrimer stabilized by carbon-Pd bonds: Synthesis, characterization and use as chemoselective, room temperature hydrogenation catalyst
Ratheesh Kumar, Venugopal K.,Gopidas, Karical R.
supporting information; experimental part, p. 3102 - 3105 (2011/06/26)
Palladium nanoparticle-cored Fréchet type G1-dendrimer (Pd-G1) stabilized by Pd-carbon bonds is synthesized and characterized by IR, NMR, UV-Vis and TEM. Pd-G1 was found to be a highly efficient, chemoselective and reusable catalyst for the room temperature hydrogenation of carbon-carbon multiple bonds. Reducible functionalities like CHO, CO, COOR, CN, NO2 and halogens were unaffected. Pd-G1 is projected as an efficient catalyst for the selective hydrogenation of carbon-carbon multiple bonds in multifunctional organic molecules.
