91508-47-3

Basic information

• Product Name: 1’-Oxo Perazine
• Synonyms: 1’-Oxo Perazine;1-(4-Methyl-1-piperazinyl)-3-(10H-phenothiazin-10-yl)-1-propanone;1-Methyl-4-(3-phenothiazin-10-ylpropionyl)piperazine;1-Methyl-4-[1-oxo-3-(10H-phenothiazin-10-yl)propyl]piperazine
• CAS NO: 91508-47-3
• Molecular Formula: C₂₀H₂₃N₃OS
• Molecular Weight: 353.48112
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 91508-47-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Solubility: Dichloromethane, Methanol
• CAS DataBase Reference: 1’-Oxo Perazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1’-Oxo Perazine(91508-47-3)
• EPA Substance Registry System: 1’-Oxo Perazine(91508-47-3)

Safety Data

• Hazardous Substances Data: 91508-47-3(Hazardous Substances Data)

Usage

Uses

Perazine intermediate.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 89755-05-5 10H-phenothiazine-10-propanoyl chloride 
• 362-04-9 methyl β-(10-phenothiazinyl)propionate 
• 1698-80-2 10H-phenothiazine-10-propanenitrile 
• 92-84-2 10H-phenothiazine 

Downstream Products

• 84-97-9 Perazin 
• 63397-92-2 3-(10H-phenothiazin-10-yl)propan-1-ol 

Relevant articles and documents

Synthesis of phenothiazine derivatives as potential inhibitors of phospholipase C

In order to study the structure-activity relationships of phenothiazine derivatives inhibiting phosphatidylinositol-specific phospholipase C (PI-PLC), the synthesis of some phenothiazine amide, amine and ester derivatives was performed mainly by reacting 10H-phenothiazine-10-propanoyl chloride with some amines and alcohols; the resulting amides were reduced with borane to yield the corresponding amines. Starting from 2-chloro and 2-trifuoromethyl-10H-phenothiazine-10-propanoyl chloride two amides were synthesized. The inhibiting activity on PI-PLC from human platelets is reported.