915100-74-2Relevant articles and documents
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
Backes, Bradley J.,Longenecker, Kenton,Hamilton, Gregory L.,Stewart, Kent,Lai, Chunqiu,Kopecka, Hana,von Geldern, Thomas W.,Madar, David J.,Pei, Zhonghua,Lubben, Thomas H.,Zinker, Bradley A.,Tian, Zhenping,Ballaron, Stephen J.,Stashko, Michael A.,Mika, Amanda K.,Beno, David W.A.,Kempf-Grote, Anita J.,Black-Schaefer, Candace,Sham, Hing L.,Trevillyan, James M.
, p. 2005 - 2012 (2008/02/01)
A novel series of pyrrolidine-constrained phenethylamines were developed as dipeptidyl peptidase IV (DPP4) inhibitors for the treatment of type 2 diabetes. The cyclohexene ring of lead-like screening hit 5 was replaced with a pyrrolidine to enable paralle