91543-45-2Relevant academic research and scientific papers
Nickel-catalyzed direct addition of diorganozinc reagents to phthalimides: Selective formation of gamma-hydroxylactams
Dennis, Joseph M.,Calyore, Catherine M.,Sjoholm, Jessica S.,Lutz, J. Patrick,Gair, Joseph J.,Johnson, Jeffrey B.
, p. 2567 - 2570 (2013/12/04)
The nickel-catalyzed addition of diorganozinc reagents to phthalimides proceeds with excellent selectivity to provide 3-substituted-3- hydroxyisoindolin-1-one products. These 3-hydroxy-γ-lactams are produced cleanly in high yield with numerous examples of imide substitution and a broad range of diorganozinc reagents that are prepared and utilized without purification. Georg Thieme Verlag Stuttgart · New York.
Reaction of N-Arylphthalisoimidium Perchlorates with Amines and Aromatic Hydrocarbons under Friedel-Crafts Conditions, a New and Convenient One-Step Method for the Synthesis of 2,3-Diaryl-3-hydroxyphthalimidines
Ismail, M. Fekry,Enayat, E. I.,El-Bassiouny, F. A.,Younes, H. A.
, p. 707 - 710 (2007/10/02)
N-Arylphthalisoimidium perchlorates (1a, b) react with primary amines via ring-opening to give N,N'-disubstituted phthalamides (3a-d).They react with aromatic hydrocarbons under Friedel-Crafts conditions to give 2,3-diaryl-3-hydroxyphthalimidines (a-i) while the reaction of 1a wtith phenylmagnesium bromide involved just deprotonation to the isoimide (9) followed by rearrangement to N-phenylphthalimide (8).
