91568-02-4Relevant academic research and scientific papers
The novel economical synthesis and antimicrobial activity of a trithiocarbonate derivative
Mabkhot, Yahia N.,Khaled, Jamal M.A.,Sultan, Mujeeb A.S.,Alharbi, Naiyf S.H.A.,Al-Showiman, Salim S.,Ghabbour, Hazem A.,Alsayari, Abdulrahman,Muhsinah, Abdullatif Bin,Algarni
, (2019)
The compound diethyl 2,2′-(thiocarbonyl-bis(sulfanediyl))-diacetate 4 belongs to the trithiocarbonate class containing a trithiocarbonate function group flanked by ethyl acetate. In this procedure, a novel economic synthesis route to obtain compound 4 is described. This compound proved to possess broad-spectrum antimicrobial activity both in vitro and in vivo, and could be used as a lead compound. It is worth mentioning that this compound has been patented [No. US 9,988,348 B1; date of patent: June 5, 2018].
Synthesis and antimicrobial use of a trithiocarbonate derivative
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Page/Page column 3; 4, (2018/06/19)
A method for preparing a trithiocarbonate derivative compound includes reacting ethyl cyanoacetate, carbon disulfide (CS2) and ethyl chloroacetate in the presence of potassium carbonate (K2CO3) in an organic solvent to produce 2,2′-(thiocarbonylbis(sulfanediyl))diacetate compound, represented by the structural formula:
Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4- thiadiazolyl)methylthio)methylene)malononitriles
Padmavathi,Dinneswara Reddy,Nagi Reddy,Mahesh
experimental part, p. 1367 - 1373 (2011/04/24)
The reactivity of ketene dithiolates in the presence of different equivalents of sodium ethoxide was studied. 2-(Bis((5-aryl-1,3,4-oxadiazol-2-yl) methylthio)methylene)malononitriles 5 and 2-(bis((5-aryl-1,3,4-thiadiazol-2-yl) methylthio)methylene)malononitriles 6 were prepared by the reaction of malononitrile with carbon disulfide and 5-aryl-2-(chloromethyl)-1,3,4- oxadiazoles 3/5-aryl-2-(chloromethyl)-1,3,4-thiadiazoles 4. The preliminary antimicrobial and antioxidant activities of the lead compounds were assayed.
New iminophosphorane-mediated synthesis of thieno[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones and 5H-2,3-dithia-5,7-diaza-cyclopenta[c,d]indenes
Liu, Ming-Guo,Hu, Yang-Gen,Ding, Ming-Wu
, p. 9052 - 9059 (2008/12/22)
Mono(iminophosphorane) 4 was selectively prepared from the reaction of 3,4-diaminothieno[2,3-b]thiophene 3 with excess triphenylphosphine, C2Cl6, and Et3N due to intramolecular double hydrogen bond formation. Mono(iminopho
SYNTHESIS OF THIENO(2,3-b)THIOPHENES AND RELATED STRUCTURES
El-Shafei, A. K.,Abdel-Ghany, H. A.,Sultan, A. A.,El-Saghier, A. M. M.
, p. 15 - 26 (2007/10/02)
Some new functionally substituted thieno(2,3-b)thiophenes and related compounds were obtained in a one-pot reaction using phase transfer catalysis conditions starting with some active nitriles or active methylene compounds, carbon disulphide or phenyl isothiocyanate and α-chlorocarbethoxy, or α-nitrile electrophiles.The structure of the obtained new compounds was assigned.Key words: Thiophene; thienothiophene; dithiolane; thiazolidinone; thiazoline; thienopyrazole; furopyrazole.
