91592-79-9

Upstream product

• 15074-54-1 2-chlorophenyl dichlorophosphate 
• 2592-95-2 benzotriazol-1-ol 
• 80817-46-5 bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate 
• 67219-55-0 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 

Downstream Products

• 91592-83-5 C₅₁H₄₈ClN₈O₁₄P 
• 91592-56-2 C₅₃H₅₁ClN₅O₁₄P 
• 91592-58-4 Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 
• 91592-57-3 C₅₉H₅₄ClN₆O₁₄P 
• 91592-59-5 C₆₇H₆₀ClN₈O₁₄P 

Relevant academic research and scientific papers

Synthesis of protected 2′-O-deoxyribonucleotides on a precipitative soluble support: a useful procedure for the preparation of trimer phosphoramidites

Tetrakis-O-(4-azidomethylphenyl)pentaerythritol, derivatized with 5′-O-(4,4′-dimethoxytrityl)-3′-O-{4-[2-(but-3-yn-1-ylamino)-2-oxoethoxy]phenoxyacetyl}thymidine, was used as a soluble support to assemble fully protected 2′-O-deoxyribonucleotide trimers b

Preparation of a disulfide-linked precipitative soluble support for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3-(2-chlorophenylphosphate) building blocks

The preparation of a disulfide-tethered precipitative soluble support and its use for solution-phase synthesis of tnmenc oligodeoxy-ribonucleotide 3′-(2-chlorophenylphosphate) building blocks is described. To obtain the building blocks, N-acyl protected 2

Synthesis of short oligodeoxyribonucleotides by phosphotriester chemistry on a precipitative tetrapodal support

Short oligodeoxyribonucleotides have been assembled from appropriately protected nucleoside 3′-(benzotriazol-1-yl 2-chlorophenyl phosphate) derivatives on hundred-milligram scales on a soluble tetrakis-O-(4- azidomethylphenyl)pentaerythritol support beari

SYNTHESIS OF DNA FRAGMENTS BY THE HYDROXYBENZOTRIAZOLE PHOSPHOTRIESTER APPROACH

The application of the phosphorylating agent 2-chlorophenyl-o,o-bis--phosphate (HOBT-approach) for the introduction of 3'-5'-phosphotriester linkages between a properly 5'-protected (4,4'-dimethoxytrityl) deoxy-nucleoside and a deoxy-nucleoside having free OH groups is described.In this way, all sixteen partially-protected DNA dimers having a free 3'-OH group have been synthesized.The dimers thus obtained have been applied, using the HOBT-approach, to the synthesis of the DNA fragments d-CGCGCG, d-CGTACG and d-ATATTAATAAC.