91599-79-0

Basic information

• Product Name: (S)-1-BENZYL-3-HYDROXYPIPERIDINE
• Synonyms: (S)-N-BENZYL-3-HYDROXYPIPERIDINE;(S)-1-BENZYL-PIPERIDIN-3-OL;(S)-1-BENZYL-3-HYDROXYPIPERIDINE;(S)-1-BENZYL-PIPERIDINOL;(S)-1-N-BENZYL-3-HYDROXY-PIPERIDINE;3-PIPERIDINOL, 1-(PHENYLMETHYL)-, (3S)-;(S)-1-Benzyl-3-piperidinol;(S)-1-Benzyl-3-hydroxypiperidi
• CAS NO: 91599-79-0
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Mol File: 91599-79-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 296.8°Cat760mmHg
• Flash Point: 113 °C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 0.000631mmHg at 25°C
• Refractive Index: n20/D 1.545±0.002
• Storage Temp.: 2-8°C
• PKA: 14.82±0.20(Predicted)
• CAS DataBase Reference: (S)-1-BENZYL-3-HYDROXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-BENZYL-3-HYDROXYPIPERIDINE(91599-79-0)
• EPA Substance Registry System: (S)-1-BENZYL-3-HYDROXYPIPERIDINE(91599-79-0)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-36/37/39-45
• RIDADR: UN2810 6.1/PG 3
• Hazardous Substances Data: 91599-79-0(Hazardous Substances Data)

Usage

General Description

(S)-1-Benzyl-3-hydroxypiperidine is a chemical compound that belongs to the class of piperidines, which are organic compounds containing a six-membered ring structure with five carbon atoms and one nitrogen atom. (S)-1-BENZYL-3-HYDROXYPIPERIDINE is a chiral molecule, meaning it has a non-superimposable mirror image, and the (S)-enantiomer has a specific orientation of atoms around the chiral center. (S)-1-Benzyl-3-hydroxypiperidine has potential applications in pharmaceutical research as it is a building block for the synthesis of various biologically active molecules. It may also be used as a precursor for the production of certain medications and drug candidates. Additionally, its unique structure and properties make it of interest for further study in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C12H17NO/c14-12-7-4-8-13(10-12)9-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2/t12-/m0/s1

Upstream product

• 40114-49-6 1-benzyl-3-piperidone 
• 100-46-9 benzylamine 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 91599-81-4 (R)-N-benzyl-3-hydroxypiperidine 
• 14813-01-5 1-benzyl-3-hydroxypiperidine 
• 108-05-4 vinyl acetate 
• 1200404-98-3 rac-N-benzyl-3-piperidinyl butanoate 
• 174621-91-1 rac-N-benzyl-3-piperidinyl acetate 
• 108-22-5 Isopropenyl acetate 
• 344-25-2 D-Prolin 
• 100-39-0 benzyl bromide 
• 53912-80-4 (S)-N-benzylprolinol 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 98584-65-7 (S)-N-benzoyl-3-hydroxypiperidine 

Downstream Products

• 625471-18-3 tert-butyl (3S)-3-aminopiperidine-1-carboxylate 
• 143900-43-0 tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate 
• 404577-34-0 (R)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester 
• 85275-46-3 tert-butyl (3R)-3-(p-tolylsulfonyloxy)piperidine-1-carboxylate 
• 940890-90-4 (S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester 
• 143900-44-1 tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate 
• 119065-61-1 (R,S)-Benidipine 
• 119065-61-1 (S,S)-Benidipine 

Relevant articles and documents

Preparation method of piperidine alcohol compound

Discloses a preparation method of a piperidinol compound, wherein the piperidinol is selected from (R)-1 - benzyl -3 - piperidinol. 1 -benzyl -3 - piperidone as reaction raw material and application thereof LiAlH4 A chiral reagent formed by the

Stereo-complementary bioreduction of saturated N-heterocyclic ketones

The asymmetric bioreduction of several saturated N-heterocyclic ketones is demonstrated in a stereo-complementary fashion using the ketoreductases READH and ChKRED20 for the production of (S)- and (R)-alcohols, respectively. The reaction accepts substrates with a five-, six- or seven-membered ring, and exhibits excellent stereoselectivity when using 2-propanol as both the ultimate reducing agent and cosolvent, achieve >99% ee in the majority of cases for both enantiomers.

Chiral-1-tert-butoxy-carbonyl-3-hydroxy-piperidine, and the preparation of chiral turning method

The invention relates to preparation of chirality-1-t-butyloxycarboryl-3-hydroxy piperidine and a method for chirality turning. The preparation mainly comprises the following steps: resolving N-benzyl-3-hydroxy piperidine as a raw material to obtain a (S) or (R)-1-benzyl-3-hydroxy piperidine camphorsulfonic acid salt, performing alkali freedom to obtain (S) or (R)-1-benzyl-3-hydroxy piperidine, performing palladium carbon hydrogenation debenzylation/t-butyloxycarboryl protection to obtain (S) or (R)-1-t-butyloxycarboryl-3-hydroxy piperidine, acylating substituting sulfonyl chloride of (R) or (S)-1-substituting-3-hydroxy piperidine as a raw material to obtain (R) or (S)-1-substituting-3-hydroxy piperidine sulfonate, substituting by using substituting carboxylate to obtain (S) or (R)-1-substituting-3-hydroxy piperidine carboxylic ester, and performing alkaline hydrolysis to obtain (S) or (R)-1-substituting-3-hydroxy piperidine. The synthesis route is gentle in reaction condition, and is applicable to industrial large-scale production.