916672-34-9Relevant academic research and scientific papers
Palladium-catalyzed regio- and diastereoselective allylic alkylation with azlactones using triphenylarsine
Kawatsura, Motoi,Ikeda, Daiji,Ishii, Tamiko,Komatsu, Yuji,Uenishi, Junichi
, p. 2435 - 2438 (2006)
The palladium-catalyzed regio- and diastereoselective allylic alkylation of (R)-2-acetoxy-4-phenyl-3-butene with azlactones using AsPh3 successfully occurred. The stereochemistries were highly controlled, and the reaction produced a coupling pr
Hydrogen-Bond Directed Regioselective Pd-Catalyzed Asymmetric Allylic Alkylation: The Construction of Chiral α-Amino Acids with Vicinal Tertiary and Quaternary Stereocenters
Wei, Xuan,Liu, Delong,An, Qianjin,Zhang, Wanbin
, p. 5768 - 5771 (2015)
A Pd-catalyzed asymmetric allylic alkylation of azlactones with 4-arylvinyl-1,3-dioxolan-2-ones was developed, providing "branched" chiral α-amino acids with vicinal tertiary and quaternary stereocenters, in high yields and with excellent selectivities. M
Palladium-catalyzed diastereo- And enantioselective allylic alkylation of oxazolones with 1,3-dienes under base-free conditions
Xing, Dong,Yang, Haijian
, p. 3721 - 3724 (2020/04/10)
Herein, we report a highly diastereo- and enantioselective allylic alkylation of oxazolones with 1,3-dienes by palladium-hydride catalyst under base-free conditions. With DTBM-SEGPHOS as the chiral ligand, a series of enantioenriched oxazolones bearing tertiary carbon centers were synthesized from substituted 1,3-dienes via exclusive 1,2-addition with moderate to good diastereoselectivities and high enantioselectivities. When simple 1,3-butadiene was used as the allyl precursor under this base-free catalytic system, 1,4-addition products were obtained in good yields with high regioselectivities.
