918148-51-3

Upstream product

• 30414-58-5 methyl 3-oxo-5-phenylpentanoate 
• 129880-16-6 3-hydroxy-5-phenyl-pentanoic acid methyl ester 
• 17071-29-3 ethyl 3-oxo-5-phenylpentanoate 
• 100-39-0 benzyl bromide 
• 540-88-5 acetic acid tert-butyl ester 
• 182417-58-9 (R)-3-hydroxy-5-phenyl-pentanoic acid ethyl ester 
• 118133-67-8 (-)-(R)-methyl 3-hydroxy-5-phenylpentanoate 

Downstream Products

• 862464-35-5 (R)-6-phenethyldihydropyran-2,4-dione 

Relevant academic research and scientific papers

Asymmetric synthesis of (6R)-4-hydroxy-6-substituted-δ-lactones

A novel approach for the asymmetric synthesis of (6R)-4-hydroxy-6-substituted-δ-lactones has been achieved using asymmetric reduction of a prochiral ketone in the presence of (S)-(?)-diphenyl-prolinol/borane as a key step. The enantiomeric purity of the products was determined by chiral GC.

Chemoenzymatic synthesis of enantiomerically enriched kavalactones

Lipase-mediated kinetic resolution of methyl-3-hydroxy-5-phenylpentanoate and (6E)-ethyl 5-hydroxy-3-oxo-7-phenylhept-6-enoate is described in high enantiomeric excess and good yields. The effect of different lipases in different solvents has been screened using different acylating agents. This protocol has been extended for the preparation of enantiomerically pure biologically important kavalactones.