91827-25-7

Upstream product

• 153-94-6 D-tryptophan 
• 98-88-4 benzoyl chloride 
• 4299-70-1 D-Tryptophan methyl ester 
• 65-85-0 benzoic acid 
• 4299-70-1 L-tryptophan methyl ester 
• 93-97-0 benzoic acid anhydride 
• 67-56-1 methanol 
• 101693-51-0 4-(1H-indol-3-ylmethyl)-2-phenyl-4H-oxazolin-5-one 

Downstream Products

• 93598-37-9 (R)-3-(1H-Indol-3-yl)-2-thiobenzoylamino-propionic acid methyl ester 
• 912270-93-0 1-benzoyl-1,2,3,8-tetrahydro-pyrrolo[2,3-b]indole-2-carboxylic acid methyl ester 
• 945038-92-6 (R)-1-Benzoyl-3a-((E)-3,7-dimethyl-octa-2,6-dienyl)-1,2,3,3a-tetrahydro-pyrrolo[2,3-b]indole-2-carboxylic acid methyl ester 
• 104330-95-2 (1R,3R)-1-phenyl-2,3,4,9-tetrahydro-1H-pyridine[3,4-b]indole-3-carboxylic acid methyl ester 
• 93598-40-4 (R)-1-Phenyl-4,9-dihydro-3H-β-carboline-3-carboxylic acid methyl ester; hydriodide 
• 55629-71-5 D-N^α-benzoyltryptophane 

Relevant academic research and scientific papers

Design, synthesis, and molecular docking studies of N-(9,10-anthraquinone-2-carbonyl)amino acid derivatives as xanthine oxidase inhibitors

A series of N-(9,10-anthraquinone-2-carbonyl)amino acid derivatives (1a–j) was designed and synthesized as novel xanthine oxidase inhibitors. Among them, the L/D-phenylalanine derivatives (1d and 1i) and the L/D-tryptophan derivatives (1e and 1j) were effective with micromolar level potency. In particular, the L-phenylalanine derivative 1d (IC50?=?3.0?μm) and the D-phenylalanine derivative 1i (IC50?=?2.9?μm) presented the highest potency and were both more potent than the positive control allopurinol (IC50?=?8.1?μm). Preliminary SAR analysis pointed that an aromatic amino acid fragment, for example, phenylalanine or tryptophan, was essential for the inhibition; the D-amino acid derivative presented equal or greater potency compared to its L-enantiomer; and the 9,10-anthraquinone moiety was welcome for the inhibition. Molecular simulations provided rational binding models for compounds 1d and 1i in the xanthine oxidase active pocket. As a result, compounds 1d and 1i could be promising lead compounds for further investigation.

Compound containing indole structure as well as preparation method and application thereof

According to the indole structure-containing compound and the preparation method thereof, the indole structure-containing compound has high biological activity on soil-borne pathogenic bacteria, fungi and nematodes, can be widely applied to prevention and treatment of soil-borne diseases, and provides material guarantee for safe production of crops.

Tris(o-phenylenedioxy)cyclotriphosphazene as a Promoter for the Formation of Amide Bonds between Aromatic Acids and Amines

The atom-efficient formation of amide bonds has emerged as a top-priority research field in organic synthesis, as amide bonds constitute the backbones of proteins and represent an important structural motif in drug molecules. Currently, the increasing demand for novel discoveries in this field has focused substantial attention on this challenging subject. Herein, the degradable 1,3,5-triazo-2,4,6-triphosphorine (TAP) motif is presented as a new condensation system for the dehydrative formation of amide bonds between diverse combinations of aromatic carboxylic acids and amines. The underlying reaction mechanism was investigated, and potential catalyst intermediates were characterized using 31 P NMR spectroscopy and ESI mass spectrometry.

Dynamic kinetic resolution: Synthesis of optically active α-amino acid derivatives

Candida antarctica lipase B (Novozyme) is an effective catalyst for the dynamic kinetic resolution of racemic 2-benzyl-4-substituted-5(4H)- oxazolones, in the presence of an alcohol, yielding optically active N- benzoyl amino acid esters. The reaction has been optimised with respect to the solvent and the effect of a catalytic amount of organic base is investigated. (C) 2000 Elsevier Science Ltd.