91833-49-7 Usage
Chemical structure
2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione is a complex organic compound consisting of a thione group (a sulfur atom double-bonded to a carbonyl carbon) and an oxazepine ring (a seven-membered ring with one oxygen and one nitrogen atom).
Thione group
The presence of a thione group (-CSH) in the compound contributes to its reactivity and potential applications in medicinal chemistry, as it can undergo various chemical reactions and form different derivatives.
Oxazepine ring
The compound contains a pyrido[3,2-f]oxazepine ring, which is a seven-membered ring with one oxygen and one nitrogen atom. This ring structure is known for its stability and can be found in various biologically active compounds.
Dimethylaminoethyl group
The presence of a 2-(dimethylamino)ethyl group (N(CH3)2) in the compound adds to its polarity and hydrogen bonding capabilities, which can influence its solubility, bioavailability, and interactions with other molecules.
Potential applications
Due to its unique molecular structure and the presence of various functional groups, 2-[2-(dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione is a potential candidate for research in medicinal chemistry and pharmacology, particularly in the development of new drugs.
Interest to scientists and researchers
The properties and potential applications of 2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione make it an interesting subject for scientists and researchers who are studying its potential medicinal uses and exploring its biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 91833-49-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,8,3 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 91833-49:
(7*9)+(6*1)+(5*8)+(4*3)+(3*3)+(2*4)+(1*9)=147
147 % 10 = 7
So 91833-49-7 is a valid CAS Registry Number.
91833-49-7Relevant academic research and scientific papers
Benzo- and pyrido-1,4-oxazepin-5-ones and -thiones: Synthesis and structure-activity relationships of a new series of H1 antihistamines
Cale Jr.,Gero,Walker,Lo,Welstead Jr.,Jaques,Johnson,Leonard,Nolan,Johnson
, p. 2178 - 2199 (2007/10/02)
A series of novel benzo- and pyrido-1,4-oxazepinones and -thiones which represents a new structural class of compounds possessing H1 antihistaminic acitivy was synthesized, and the SARs were evaluated. The antihistamine activity was determined by blockade of histamine-induced lethality in guinea pigs. The sedative potential was determined by comparison of the EEG profiles of the compounds with those of known sedating and nonsedating antihistamines. Several of the compounds were shown to possess potent H1 antihistaminic activity and to be free of the cortical slowing with synchronized waves and spindling activity found in the EEG of sedative antihistamines. One compound, 2-[2-(dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazeN pine-5(2H)-thione (rocastine) is currently undergoing clinical evaluation as a nonsedating H1 antihistamine.
