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BCX-4161 is a novel, orally bioavailable, and selective small molecule inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), which plays a crucial role in the de novo pyrimidine synthesis pathway. This pathway is essential for the proliferation of rapidly dividing cells, such as cancer cells and certain autoimmune cells. By inhibiting DHODH, BCX-4161 disrupts the pyrimidine synthesis, leading to the depletion of uridine monophosphate (UMP) and subsequent cell cycle arrest and apoptosis in cancer cells. This targeted approach has shown potential in the treatment of various cancers, including acute myeloid leukemia (AML), and autoimmune diseases like systemic lupus erythematosus (SLE). Clinical trials are underway to evaluate the safety, tolerability, and efficacy of BCX-4161 in these indications.

918407-35-9

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918407-35-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 918407-35-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,8,4,0 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 918407-35:
(8*9)+(7*1)+(6*8)+(5*4)+(4*0)+(3*7)+(2*3)+(1*5)=179
179 % 10 = 9
So 918407-35-9 is a valid CAS Registry Number.

918407-35-9Downstream Products

918407-35-9Relevant academic research and scientific papers

METHOD FOR PRODUCING AMIDINE DERIVATIVES

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, (2016/03/18)

The invention provides methods and intermediates useful in the synthesis of a compound of formula (I): or a pharmaceutically acceptable salt, solvate, ester or prodrug thereof; wherein the variables are as defined herein.

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