918879-55-7Relevant articles and documents
Microwave-assisted rapid and straightforward synthesis of novel 6-(aroxymethyl)-2-aryl-6,7-dihydropyrazolo[5,1-c][1,4]oxazin-4-one derivatives
Wei, Fang,Zhao, Bao-Xiang,Dong, Wen-Liang,Zuo, Hua,Shin, Dong-Soo,Wang, Da-Wei,Xia, Yong,Ge, Yan-Qing
, p. 4415 - 4424 (2008/03/14)
A series of novel 6-(aroxymethyl)-2-aryl-6,7-dihydropyrazolo[5,1-c][1,4] oxazin-4-one derivatives was synthesized from ethyl 3-aryl-1H-pyrazole-5- carboxylate and 2-aryloxymethylepoxide by a microwave-assisted, one-step method in good yields. The microwave-assisted reaction of ethyl 3-aryl-1H-pyrazole-5- carboxylate and 2-aryloxymethylepoxide proceeds with higher regioselectivity and is more economical and environmentally friendly in contrast to the normal intramolecular esterification route. A tandem mechanism of the reaction was proposed. Copyright Taylor & Francis Group, LLC.