918892-30-5

Usage

Uses

Used in Organic Synthesis:
A-Tosyl-(4-chlorobenzyl) isocyanide is used as a versatile building block for the preparation of various functionalized compounds. Its reactivity with a wide range of nucleophiles makes it an essential tool in the development of new synthetic methodologies.
Used in Pharmaceutical Industry:
A-Tosyl-(4-chlorobenzyl) isocyanide is used as a precursor in the synthesis of pharmaceuticals. Its unique properties and reactivity contribute to the creation of new and effective drugs for various medical applications.
Used in the Synthesis of Biologically Active Compounds:
A-Tosyl-(4-chlorobenzyl) isocyanide is also employed in the synthesis of biologically active compounds, which have potential applications in various fields such as medicine, agriculture, and environmental science. Its role as a precursor allows for the development of novel compounds with specific biological activities.

InChI:InChI=1/C15H12ClNO2S/c1-11-3-9-14(10-4-11)20(18,19)15(17-2)12-5-7-13(16)8-6-12/h3-10,15H,1H3

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 104-15-4 toluene-4-sulfonic acid 
• 536-57-2 p-toluene sulfinic acid 
• 657-84-1 sodium tosylate 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 151359-62-5 4,5-bis(4-chlorophenyl)-1,3-oxazole 

Relevant academic research and scientific papers

A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes

Chemical probes for epigenetic proteins are essential tools for dissecting the molecular mechanisms for gene regulation and therapeutic development. The bromodomain and extra-terminal (BET) proteins are master transcriptional regulators. Despite promising

The base-free van Leusen reaction of cyclic imines on water: Synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives

Construction of imidazoles has been demonstrated on water under base-free conditions. The reaction of dihydro β-carboline imines and p-toluenesulfonylmethyl isocyanides furnished the corresponding substituted N-fused imidazo 6,11-dihydro β-carboline derivatives in very good yields under ambient conditions. The use of deuterium oxide (D2O) as a solvent enabled the incorporation of deuterium isotopes in the imidazole ring.

Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents

We have designed and synthesized a series of new imidazole-based compounds structurally related to an antiprotozoal agent with nanomolar activity which we identified recently. The new analogues possess micromolar activities against Trypanosoma brucei rhod

COMPOUNDS FOR THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to new compounds that are useful in the prevention or treatment of respiratory diseases, such as asthma, to the preparation of the compounds, and to compositions including the compounds. The present invention also relates to the use of the compounds, as well as compositions including the compounds, in treating or preventing respiratory diseases.

LXR MODULATORS

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.

Synthesis, biological evaluation, and molecular modeling studies of novel heterocyclic compounds as anti-proliferative agents

Two novel series of heterocyclic compounds have been synthesized. In first series, isatin was allowed to react with substituted aromatic/cyclic carbonyl compounds to get desired mannich bases (2a-e). In second series, 4,5-disubstituted oxazoles (6a-p) wer