918892-30-5Relevant articles and documents
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes
Aihara, Hideki,Cui, Huarui,Divakaran, Anand,Ellingson, Mikael O.,Gee, Clifford T.,Griffith, Elizabeth C.,Harki, Daniel A.,Hoell, Zachariah J.,Johnson, Jorden A.,Khanal, Shalil,Lee, Amani L.,Lee, Richard E.,Pomerantz, William C. K.,Scholtz, Cole R.,Shah, Vijay H.,Shi, Ke,Zahid, Huda
supporting information, (2022/01/27)
Chemical probes for epigenetic proteins are essential tools for dissecting the molecular mechanisms for gene regulation and therapeutic development. The bromodomain and extra-terminal (BET) proteins are master transcriptional regulators. Despite promising
The base-free van Leusen reaction of cyclic imines on water: Synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives
Satyam, Killari,Murugesh,Suresh, Surisetti
supporting information, p. 5234 - 5238 (2019/06/07)
Construction of imidazoles has been demonstrated on water under base-free conditions. The reaction of dihydro β-carboline imines and p-toluenesulfonylmethyl isocyanides furnished the corresponding substituted N-fused imidazo 6,11-dihydro β-carboline derivatives in very good yields under ambient conditions. The use of deuterium oxide (D2O) as a solvent enabled the incorporation of deuterium isotopes in the imidazole ring.
LXR MODULATORS
-
Page/Page column 168, (2014/09/29)
The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.