91921-99-2

Upstream product

• 86694-74-8 ethyl 1-(2,4-dimethoxybenzyl)-4-oxo-2-azetidine-carboxylate 
• 81902-49-0 diethyl N-(2,4-dimethoxybenzyl)-amino-malonate 
• 86694-72-6 diethyl N-(2,4-dimethoxy-benzyl)-N-(chloroacetyl)-amino-malonate 
• 86694-73-7 Diethyl 1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidine-dicarboxylate 

Downstream Products

• 91921-97-0 (4RS)-4-diazoacetyl-1-(2,4-dimethoxybenzyl)azetidin-2-one 
• 94271-73-5 2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester 
• 94271-74-6 4-[1-(2,4-Dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester 
• 104429-99-4 [1-(2,4-Dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetic acid benzhydryl ester 
• 91921-98-1 [1-(2,4-dimethoxy-benzyl)-4-oxo-2-azetidinyl]-acetic acid 
• 103841-23-2 1-(2,4-dimethoxybenzyl)-4-oxoazetidine-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Azetidinone acetic acid derivatives and process for the preparation thereof

The invention relates to compounds of the general formula (X) STR1 wherein R is as a removable protecting substituent of the amido group a phenyl group or a benzyl group substituted by one or more alkoxy group(s) having 1-4 carbon atoms and R1 stands for a hydrogen atom or an alkyl group having 1-4 carbon atoms and a process for the preparation thereof. The compounds of the general formula (X) can be prepared from the starting materials of the general formula (V), wherein R and R1 are as stated above and Z is an alkyl group having 1-4 carbon atoms. The compounds of the general formula (X) are useful pharmaceutical intermediates which can be used in the preparation of known antibiotics (e.g. Thienamycin and PS-5).