91922-04-2

Upstream product

• 22118-12-3 2-bromobutanoyl chloride 
• 81902-49-0 diethyl N-(2,4-dimethoxybenzyl)-amino-malonate 
• 102357-51-7 2-[(2-Bromo-butyryl)-(2,4-dimethoxy-benzyl)-amino]-malonic acid diethyl ester 

Downstream Products

• 79252-33-8 3-ethyl-4-(2-oxo-3-p-nitrobenzyloxycarbonylpropyl)azetidin-2-one 

Relevant academic research and scientific papers

Azetidinone acetic acid derivatives and process for the preparation thereof

The invention relates to compounds of the general formula (X) STR1 wherein R is as a removable protecting substituent of the amido group a phenyl group or a benzyl group substituted by one or more alkoxy group(s) having 1-4 carbon atoms and R1 stands for a hydrogen atom or an alkyl group having 1-4 carbon atoms and a process for the preparation thereof. The compounds of the general formula (X) can be prepared from the starting materials of the general formula (V), wherein R and R1 are as stated above and Z is an alkyl group having 1-4 carbon atoms. The compounds of the general formula (X) are useful pharmaceutical intermediates which can be used in the preparation of known antibiotics (e.g. Thienamycin and PS-5).

SIMPLE AND CONDENSED β-LACTAMS. Part 6. A Synthesis of the p-Nitrobenzyl Esters of the Racemic Forms of the Carbapenem Antibiotics PS-5 and PS-6, and of Their 6-Epimers.

The p-nitrobenzyl esters of the racemic carbapenem antibiotics PS-5 and PS-6, and of their 6-epimers were synthesised starting with the trans (6a, 6c) and cis forms (6b, 6d) of ethyl 1-(2,4-dimethoxybenzyl)-4-oxo-2-azetidinecarboxylates, respectively.