91969-86-7Relevant academic research and scientific papers
Highly chemo- and regioselective reaction of hydroxybenzenes in acidic ionic liquid
Guo, Hui,Zhuang, Yu Wei,Cao, Jian,Zhang, Guo Bao
, p. 2594 - 2596 (2013/10/22)
Highly chemo- and regioselective reaction of hydroxybenzenes with α,β-unsaturated compounds in acidic ionic liquid l-butyl-3- methylimidazolium hydrogen sulphate ([BMIM]HSO4) was reported for the first time. A series of oxa-Michael adducts and Friedel-Crafts alkylated products were synthesized with good yields. The acidic ionic liquid could be easily recycled for at least 5 times with only minor loss in activity.
About the "physiological size" of fluorine substituents : Comparison of sensorially active compounds with fluorine and methyl substituted analogues
Schlosser, Manfred,Michel, Dominique
, p. 99 - 108 (2007/10/02)
The taste of four fluoro substituted derivatives (2a, 2b, 2c and 2d) is almost indistinguishable from that of the parent compound 4-(4-hydroxyphenyl)butan-2-one (1), the main flavor component of raspberries. The same holds for the comparison between the corresponding acetate, another raspberry ingredient, and its 1-fluoro analogue (2e). In contrast, methyl substituents (as present in compounds 3a, 3b, 3c, 3d and 3e) profoundly alter the organoleptic properties. - The preparation of the fluorinated derivatives (2) involved the three principal options existing for the incorporation of fluorine into organic molecular skeletons : the use of "prefabricates" (i.e., of fluoroaromatic building blocks), the formation of chlorofluorocarbene cycloadducts followed by their solvolytic ring opening and the addition of fluoride to olefinic double bonds. Copyright
AMBERLYST-15 CATALYZED ADDITION OF PHENOLS TO α,β-UNSATURATED KETONES
Bunce, Richard A.,Reeves, Henry D.
, p. 1109 - 1118 (2007/10/02)
Amberlyst-15 has been used to catalyze regioselective additions of phenols to α,β-unsaturated ketones in yields of 20-90percent.The reaction is superior to the analogous reaction employing concentrated sulfuric acid in affording greater yields and purer products with a minimum of laboratory operations.
