92029-41-9

Usage

Uses

Used in Pharmaceutical Industry:
2-P-Tolyl-oxazole-4-carboxylic acid ethyl ester is used as a key intermediate in the synthesis of various prescription drugs. Its unique structure allows for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Production:
2-P-TOLYL-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER also serves as an important intermediate in the production of agrochemicals, which are chemicals used in agricultural processes to protect crops and enhance their growth. Its role in agrochemical synthesis contributes to the development of effective and targeted pest control solutions.
Safety Precautions:
It is crucial to handle 2-P-Tolyl-oxazole-4-carboxylic acid ethyl ester with proper safety measures, as it may have harmful effects if not used appropriately. This includes wearing protective gear, working in well-ventilated areas, and following established safety protocols to minimize risks associated with its use.

Upstream product

• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-59-9 p-toluenesulfonyl chloride 
• 70-23-5 ethyl Bromopyruvate 
• 619-55-6 para-methylbenzamide 
• 5720-05-8 4-methylphenylboronic acid 
• 460081-20-3 2-bromo-4-(ethoxycarbonyl)-1,3-oxazol-5-ylium 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1139705-26-2 4-methylphenyl imidazolesulfonate 
• 14762-48-2 ethyl 2-diazo-3-oxo-propanoate 
• 104-85-8 para-methylbenzonitrile 
• 97723-17-6 2-(ethoxy-p-tolyl-methyleneamino)-3-oxo-propionic acid ethyl ester; potassium salt 

Downstream Products

• 111164-86-4 2-p-tolyl-oxazole-4-carboxylic acid amide 
• 91137-54-1 2-(4-methylphenyl)-1,3-oxazole-4-carboxylic acid 
• 1373156-35-4 C₁₃H₁₂BrNO₃ 
• 1373156-43-4 C₂₇H₂₃NO₄ 
• 1373156-13-8 C₂₅H₁₉NO₄ 
• 934610-13-6 ethyl 5-phenyl-2-(p-tolyl)oxazole-4-carboxylate 
• 95174-27-9 2-p-tolyl-oxazole-4-carbothioic acid amide 
• 91135-46-5 2-p-tolyl-oxazole-4-carbonitrile 
• 97789-38-3 2-p-tolyl-thiazole-4-carbothioic acid anilide 
• 93323-66-1 2-p-tolyl-oxazole-4-carboxylic acid anilide 

Relevant academic research and scientific papers

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

Design, synthesis and biological evaluation of 2,4-disubstituted oxazole derivatives as potential PDE4 inhibitors

In this study, a series of pyrazole derivatives containing 4-phenyl-2-oxazole moiety were designed and synthesized in a concise way, some of which exhibited considerable inhibitory activity against PDE4B and blockade of LPS-induced TNF-α release. Compound

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

Histone deacetylase 6 (HDAC6) catalyzes the removal of an acetyl group from lysine residues of several non-histone proteins. Here we report the preparation of thiazole-, oxazole-, and oxadiazole-containing biarylhydroxamic acids by a short synthetic proce

Palladium-catalyzed desulfitative arylation of azoles with arylsulfonyl hydrazides

Palladium-catalyzed desulfitative and denitrogenative arylation of azoles with arylsulfonyl hydrazides has been achieved. A broad scope of azoles and arylsulfonyl hydrazides has been used to produce arylated azoles in high yields.

A highly efficient palladium-catalyzed desulfitative arylation of azoles with sodium arylsulfinates

A highly efficient palladium-catalyzed direct desulfitative arylation of azoles at C2-position has been developed using sodium arylsulfinates as aryl sources. Azoles including benzoxazoles, benzothiazoles, oxazoles, thiazoles, and 1,3,4-oxadiazoles reacted with sodium arylsulfinates smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction.

Palladium-catalyzed direct arylations, alkenylations, and benzylations through C-H bond cleavages with sulfamates or phosphates as electrophiles

(Figure Presented) catalytic system comprised of Pd(OAc)2 and bldentate ligand dppe enabled first direct arylatlons with moisture-stable aryl sulfamates as electrophlles, and proved applicable to unprecedented C-H bond functlonallzations with e

Rhodium-catalyzed heterocycloaddition route to 1,3-oxazoles as building blocks in natural products synthesis

Rhodium(II) acetate serves as a catalyst for the heterocycloaddition reaction of diazodicarbonyl compounds with nitriles to give functionalized 1,3-oxazole derivatives in a simple one-step procedure. In particular, dimethyl diazomalonate undergoes this re

DIRECT PREPARATION OF 4-CARBOETHOXY-1,3-OXAZOLES

The diazoaldehyde ester N2C(CHO)CO2Et undergoes rhodium-catalyzed reaction with nitriles to give 4-carboethoxy-1,3-oxazoles directly.