92126-30-2

Upstream product

• 110-65-6 1,4-dihydroxybut-2-yne 
• 873-67-6 benzonitrile oxide 
• 100-52-7 benzaldehyde 
• 698-16-8 benzohydroximoyl chloride 
• 7710-44-3 dimethyl 3-phenylisoxazole-4,5-dicarboxylate 

Downstream Products

• 137384-57-7 4,5-bis(bromomethyl)-3-phenyl-isoxazole 
• 92126-31-3 3-phenyl-4,5-bis(hydroxymethyl)isoxazole bis(methylcarbamate) 
• 137384-60-2 3-Phenyl-4,7-dihydro-isoxazolo[4,5-d]pyridazine-5,6-dicarboxylic acid diethyl ester 
• 137384-59-9 3,6-Diphenyl-4,4a,7a,8-tetrahydro-isoxazolo[4,5-f]isoindole-5,7-dione 
• 137384-58-8 4,5-Dimethylene-3-phenyl-4,5-dihydro-isoxazole 
• 143950-64-5 3,3-bis(2,6-dichlorophenyl)-3'-phenyl-isoxazole-5(4H)-spiro-5'-isoxazole-4'-spiro-5(4H)-isoxazole 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS WITH MICROBIOCIDAL PROPERTIES

The present disclosure relates to a compound of Formula I, wherein the substituents T, A, W, R2, n, Z, G, Z1 and J are as defined in the description.

Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes

Treatment of oximes with hypervalent iodine leads to substituted isoxazoles via rapid formation of nitrile oxides. Reaction with terminal alkynes led to a series of 3,5-disubstituted isoxazoles with complete regioselectivity and high yield, in a procedure

Spiroheterocycles from reaction of nitrile oxides with heterocyclic o-quinodimethanes

1,3-Dipolar cycloaddition to o-quinodimethanes has been observed for the first time in the reaction of pyrazole and isoxazole o-quinodimethanes 4-6 with the stable nitrile oxides 7 and 8. The products, dispiroisoxazolines 9-14, were isolated in moderate y

The isoxazole analogue of ortho-quinodimethane: Generation and cycloaddition reactions

4,5-Dihydro-4,5-dimethylene-3-phenyl-isoxazole (the isoxazole analogue of ortho-quinodimethane) has been generated in situ from 4,5-bis(bromomethyl)-3-phenyl-isoxazole by sodium iodide induced 1,4-elimination process and trapped with symmetrical and unsymmetrical dienophiles.

Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents

A series of bis(hydroxymethyl)-substituted heterocycles were synthesized and converted to the corresponding bis(methylcarbamate) derivatives. The heterocyclic systems studied were based on 2-phenyl-3-methylfuran, 1-phenylpyrazole, 1-phenyl-5-methylpyrazole, 1-phenyl-5-methylthiopene, 1-phenyl-1,2,3-triazole, 3-phenylisoxazole, 3-phenylisothiazole, 2-phenylthiazole, and 2-phenyloxazole. None of the bis(carbamates) prepared was active against murine P388 lymphocytic leukemia. Pyrrole bis(carbamate), which exhibited antileukemic activity, also showed reactivity toward 4-(p-nitrobenzyl)pyridine while the inactive bis(carbamates) were unreactive in the 4-(p-nitrobenzyl)pyridine assay.