7710-44-3

Upstream product

• 698-16-8 benzohydroximoyl chloride 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 622-42-4 1-nitro-1-phenylmethane 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 19279-25-5 5-phenyl-1,3,2,4-dioxathiazole 2-oxide 
• 873-67-6 benzonitrile oxide 
• 947-57-9 dimethyl bicyclo[2.2.1]hept-2,5-diene-2,3-dicarboxylate 
• 19019-88-6 7-isopropylidene-2,3-dicarbomethoxynorbornadiene 
• 1829-60-3 dimethyl 7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate 
• 100-52-7 benzaldehyde 
• 932-90-1 Benzaldoxime 
• 110-91-8 morpholine 
• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 
• 98-86-2 acetophenone 

Downstream Products

• 112330-20-8 methyl 5-carbamoyl-3-phenylisoxazole-4-carboxylate 
• 112330-19-5 methyl 5-(N-benzimidoylcarbamoyl)-3-phenylisoxazole-4-carboxylate 
• 1236189-18-6 4-(methoxycarbonyl)-3-phenylisoxazole-5-carboxylic acid 
• 137384-60-2 3-Phenyl-4,7-dihydro-isoxazolo[4,5-d]pyridazine-5,6-dicarboxylic acid diethyl ester 
• 137384-59-9 3,6-Diphenyl-4,4a,7a,8-tetrahydro-isoxazolo[4,5-f]isoindole-5,7-dione 
• 137384-58-8 4,5-Dimethylene-3-phenyl-4,5-dihydro-isoxazole 
• 143950-64-5 3,3-bis(2,6-dichlorophenyl)-3'-phenyl-isoxazole-5(4H)-spiro-5'-isoxazole-4'-spiro-5(4H)-isoxazole 
• 137384-57-7 4,5-bis(bromomethyl)-3-phenyl-isoxazole 
• 92126-31-3 3-phenyl-4,5-bis(hydroxymethyl)isoxazole bis(methylcarbamate) 
• 92126-30-2 3-phenyl-4,5-bis(hydroxymethyl)isoxazole 
• 76240-13-6 methyl 9-oxo-3,6-diphenyl-7-(phenylimino)-1-oxa-2,6,8-triazaspiro<4.4>non-3-ene-4-carboxylate 

Relevant academic research and scientific papers

Microwave-assisted 1,3-dipolar cycloaddition reactions of nitrilimines and nitrile oxides

The 1,3-dipolar activity of hydrazonoyl chlorides and oxime chlorides over alumina with various alkenes and alkynes under microwave irradiation is studied; a comparative study between dry media conditions and the procedure in homogeneous solution under microwave and classical heating is described.

α-Nitrosostyrenes as Three-Atom Units for the (3+1) Cyclization Reaction: Facile Access to 2,3-Dihydrodiazete N-Oxides and Their Diversified Synthetic Conversions

An unprecedented (3+1) cyclization of α-nitrosostyrenes, generated in situ from α-bromooximes, and N-tosyloxycarbamates was developed, which enables the synthesis of a range of structurally unique and hitherto unexplored 2,3-dihydrodiazete N-oxides in mod

Heterocycle-Heterocycle Strategy for 4,5-Disubstituted Pyrrolidine 2,3-Diones: Reductive Rearrangement Approach from Isoxazole Esters

The work demonstrates the heterocycle-heterocycle interconversion strategy to access 4,5-disubstituted 3-hydroxy-2-pyrrolidinone in moderate to good yields (50-80%). The approach has a distinct advantage over a multicomponent reaction approach as it allow

Copper nitrate-mediated synthesis of 3-aryl isoxazolines and isoxazoles from olefinic azlactones

A copper nitrate-mediated [2 + 2 + 1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting 3-aryl substituted isoxazolines and isoxazoles through CC bond cleavage. Copper nitrate is employed as a reaction promoter and precursor of nitrile oxides. The given approach features a new mode of cycloaddition from olefinic azlactones, copper nitrate and unsaturated compounds with wide substrate scope, good functional group tolerance and operational simplicity.

HETEROCYCLIC COMPOUNDS WITH MICROBIOCIDAL PROPERTIES

The present disclosure relates to a compound of Formula I, wherein the substituents T, A, W, R2, n, Z, G, Z1 and J are as defined in the description.

Synthesis of five-membered cyclic nitrones based on the Lewis acid-catalysed [3+2]-annulation reaction of donor-acceptor cyclopropanes with 1,4,2-dioxazoles

A novel synthesis of five-membered cyclic nitrones has been developed based on the Lewis acid-catalysed [3+2]-annulation reaction of D-A cyclopropanes with 1,4,2-dioxazoles. Broad substrate scope and generally good yield make this reaction useful in the p

Hypervalent iodine mediated synthesis of di- and tri-substituted isoxazoles via [3+2] cycloaddition of nitrile oxides

An efficient and rapid protocol for the synthesis of 3,4-disubstituted and 3,4,5-trisubstituted isoxazoles under catalyst-free conditions is described. This protocol involves pre-oxidation of aldoxime into nitrile oxide using diacetoxyiodobenzene. The in

SUBSTITUTED OXADIAZOLE DERIVATIVES AS S1P AGONISTS IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES

Disclosed are compounds of Formula (I) [INSERT CHEMICAL STRUCTURE HERE] (I) or pharmaceutically acceptable salts thereof, wherein Q is [INSERT CHEMICAL STRUCTURE HERE] or [INSERT CHEMICAL STRUCTURE HERE]; R1 is alkyl or aryl, said aryl optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Lanthanide triflate-catalyzed 1,3-dipolar cycloaddition reactions of polymer-supported nitrones with alkenes for the preparation of diverse 2- isoxazoline derivatives

1,3-Dipolar cycloaddition reactions of polymer-supported nitrones with alkenes proceeded smoothly in the presence of a catalytic amount of a lanthanide triflate to afford the corresponding 2-isoxazolines in high yields. Diverse 2-isoxazoline derivatives were prepared based on these solid- phase reactions.

Synthesis and Herbicidal Activity of Isoxazoledicarboxylic Acid Derivatives

Starting from bulk chemicals, novel isoxazoledicarboxylic acid esters were prepared and converted to the corresponding dicarboxylic acid monoamides in a few reaction steps and in high overall yields. Key intermediates for the cycloaddition step were chlor