92161-47-2

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 73011-26-4 6-methoxy-3H-benzo[d][1,2,3]dithiazole 2-oxide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 2941-58-4 2-bromo-6-methoxy-1,3 benzothiazole 
• 99-91-2 para-chloroacetophenone 
• 6274-29-9 2-amino-5-methoxy-thiophenol 
• 2942-13-4 6-methoxy-1,3-benzothiazole 
• 104-86-9 4-chlorobenzylamine 
• 2182-73-2 6-methoxybenzo[d]thiazole-2(3H)-thione 

Relevant academic research and scientific papers

Efficient 2-aryl benzothiazole formation from aryl ketones and 2-aminobenzenethiols under metal-free conditions

2-Aryl benzothiazole formation from aryl ketones and 2-aminobenzenethiols under metal- and I2-free conditions was described. Various 2-aryl benzothiazoles were selectively obtained in good yields using molecular oxygen as oxidant. DMSO played an important role in this transformation. Functional groups such as methyl, methoxy, fluoro, chloro, bromo and nitro groups were tolerated under the optimized reaction conditions.

An efficient desulfitative C-C cross coupling of fused thiazolidine-2-thione with boronic acids and boronic acid pinacol esters: Formation of fused thiazoles

An efficient Pd(0)-catalyzed Cu(i)-mediated desulfitative C-C cross-coupling of benzo-fused thiazolidine-2-thione with boronic acids under neutral Liebeskind-Srogl conditions is described. The desulfitative cross coupling of boronic acid pinacol esters has also been demonstrated with fused thiazolidine-2-thione under basic conditions to afford fused thiazoles with good to excellent yields.

Synthesis of 2-aryl benzothiazoles via K2S2O 8-mediated oxidative condensation of benzothiazoles with benzylamines

A novel way to synthesize 2-arylbenzothiazoles is described. Reactions of benzothiazoles with diverse benzylamines in the presence of K2S 2O8 and KOt-Bu in DMSO-H2O afforded the desired 2-arylbenzothiazoles in good yields. It is notable that no transition-metal catalyst is needed in this reaction. Compared with other known methods, this method of synthesizing 2-arylbenzothiazoles can be advantageous in cases where substituted benzothiazoles and benzylamines are readily available. Georg Thieme Verlag Stuttgart. New York.

A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution

We measured the "draggability" of the ATP-dependent luciferase derived from the firefly Photuris pennsylvanica that was optimized using directed evolution (Ultra-Glo, Promega). Quantitative high-throughput screening (qHTS) was used to determine IC50

3-H-1,2,3-Benzodithiazole-2-oxides as synthons for the synthesis of five- and six-membered heterocycles containing sulphur and nitrogen

The reaction of 6-substituted-1,2,3-benzodithiazole-2-oxides (2) with aromatic aldehydes, carboxylic acids and acid chlorides in the presence of an organic base such as triethylamine and N,N-dimethylaniline lead to the formation of 6-substituted-2-arylben