92176-52-8

Upstream product

• 6163-66-2 2,2'-oxybis(2-methyl-propane) 
• 4313-73-9 N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-L-leucine 
• 92176-58-4 Trityl-L-phenylalanylbenzotriazolylester 
• 21691-53-2 L-leucine tert-butyl ester 
• 104-15-4 toluene-4-sulfonic acid 
• 92176-51-7 Trt-Phe-Leu-OtBu 

Downstream Products

• 104190-39-8 N,N'-(2,2'-dithiobisbenzoyl)bis[L-phenylalanyl-L-leucine,1,1-dimethylethyl ester] 
• 92176-53-9 Trt-Gly-Phe-Leu-OtBu 

Relevant academic research and scientific papers

CARBOXY AND SUBSTITUTED CARBOXY ALKANOYL AND CYCLOALKANOYL PEPTIDES

Peptides of the formula STR1 wherein X is various amino or imino acids or esters are useful as hypotensive agents.

MERCAPTOCYCLOALKYLCARBONYL AND MERCAPTOARYLCARBONYL DIPEPTIDES

Compounds of the formula STR1 wherein A is a cycloalkyl ring, a substituted cycloalkyl ring, a phenyl ring, or a substituted phenyl ring and STR2 are various dipeptide groups are disclosed. The compounds possess angiotensin converting enzyme inhibition activity and depending upon the terminal amino acid may also possess enkephalinase inhibition activity.

Application of N-Tritylamio Acid 1-Benzotriazolyl Esters in Peptide Synthesis

The application of N-tritylamino acid 1-benzotriazolyl esters 2 in peptide synthesis is investigated using as model compounds leucine-enkephalin (18) and leucine-enkephalinamide (19).The reactions are performed in solution and on the surface of solids.New spectrophotometric methods, based on the facile cleavage of the N-trityl group and on the measurement of the absorbance of the released triphenylmethanol, are used to monitor the coupling steps and to determine the free amino groups on the solid carrier.