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Trityl-L-phenylalanylbenzotriazolylester, also known as Trt-Phe-Bt, is a chemical compound commonly used in peptide synthesis. It is a protected amino acid derivative, where the phenylalanine (Phe) residue is protected by a trityl (Trt) group and a benzotriazol-2-yloxytris(pyrrolidino)phosphonium hexafluorophosphate (PyBOP) coupling agent. This protection is essential to prevent unwanted side reactions during the synthesis process. The benzotriazolylester (Bt) group is used to protect the carboxyl group of the phenylalanine, allowing for selective deprotection and coupling reactions in peptide synthesis. Trt-Phe-Bt is a valuable component in the construction of complex peptide sequences, as it enables chemists to control the reactivity and selectivity of individual amino acid residues, ultimately leading to the formation of desired peptide structures with high purity and yield.

92176-58-4

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92176-58-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 92176-58-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,1,7 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 92176-58:
(7*9)+(6*2)+(5*1)+(4*7)+(3*6)+(2*5)+(1*8)=144
144 % 10 = 4
So 92176-58-4 is a valid CAS Registry Number.

92176-58-4Relevant academic research and scientific papers

Reaction of N-trityl amino acids with BOP: Efficient synthesis of t-butyl esters as well as N-trityl serine- and threonine-β-lactones

Sliedregt, Karen M.,Schouten, Arie,Kroon, Jan,Liskamp, Rob M.J.

, p. 4237 - 4240 (1996)

Upon exposure to methoxymethylamine and BOP, the stable hydroxybenzotriazolyl amide of TrPheOH was isolated instead of the expected Weinreb amide. This amide behaves as an active amide similar to the Weinreb amide and could be used, among others, for the

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