922166-91-4

Basic information

• Product Name: 2,4,8-Pentadecatrienoic acid, 15-[3-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2,5-dimethoxyphenyl]-7- hydroxy-6,11,12,15-tetramethoxy-2,8,10,14-tetramethyl-, ethyl ester, (2E,4Z,6S,7S,8E,10S,11R,12S,14S,15R)-
• CAS NO: 922166-91-4
• Molecular Formula: C43H69NO13
• Molecular Weight: 808.02
• Mol File: 922166-91-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4,8-Pentadecatrienoic acid, 15-[3-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2,5-dimethoxyphenyl]-7- hydroxy-6,11,12,15-tetramethoxy-2,8,10,14-tetramethyl-, ethyl ester, (2E,4Z,6S,7S,8E,10S,11R,12S,14S,15R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,8-Pentadecatrienoic acid, 15-[3-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2,5-dimethoxyphenyl]-7- hydroxy-6,11,12,15-tetramethoxy-2,8,10,14-tetramethyl-, ethyl ester, (2E,4Z,6S,7S,8E,10S,11R,12S,14S,15R)-(922166-91-4)
• EPA Substance Registry System: 2,4,8-Pentadecatrienoic acid, 15-[3-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2,5-dimethoxyphenyl]-7- hydroxy-6,11,12,15-tetramethoxy-2,8,10,14-tetramethyl-, ethyl ester, (2E,4Z,6S,7S,8E,10S,11R,12S,14S,15R)-(922166-91-4)

Safety Data

• Hazardous Substances Data: 922166-91-4(Hazardous Substances Data)

Upstream product

• 115929-59-4 6-bromo-4-methoxy-2-nitrophenol 
• 137788-08-0 (2S,4S,5R,6S,7E,9S,10S)-9-<(t-butyldimethylsilyl)oxy>-4,5,10-trimethoxy-2,6,8-trimethyl-7,11-dodecadienal 
• 145798-86-3 (2S,4S,5R,6S,7E,9S,10S)-9-<(t-butyldimethylsilyl)oxy>-4,5,10-trimethoxy-2,6,8-trimethyl-7,11-dodecadien-1-ol 
• 123444-68-8 (S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutanal 
• 55034-12-3 6-bromo-1,4-dimethoxy-2-nitrobenzene 
• 115929-62-9 3-bromo-2,5-dimethoxyaniline 
• 1568-70-3 4-methoxy-2-nitrophenol 
• 922166-95-8 C₄₃H₇₅NO₁₁Si 
• 922166-88-9 (E)-(3S,4S,7S,8R,9S,11S,12R)-12-[3-bis(tert-butoxycarbonyl)amino-2,5-dimethoxyphenyl]-3,8,9,12-tetramethoxy-5,7,11-trimethyldodeca-1,5-dien-4-yl acrylate 
• 922166-83-4 (E)-(1R,2S,4S,5R,6S,9S,10S)-9-tert-butyldimethylsilyloxy-1-(3-diallylamino-2,5-dimethoxyphenyl)-4,5,10-trimethoxy-2,6,8-trimethyldodec-7,11-dien-1-ol 
• 922166-94-7 (E)-N,N-diallyl-N-{3-[(1R,2S,4S,5R,6S,9S,10S)-9-tert-butyldimethylsilyloxy-1,4,5,10-tetramethoxy-2,6,8-trimethyldodec-7,11-dienyl]-2,5-dimethoxyphenyl}amine 
• 922166-90-3 C₃₈H₅₉NO₁₂ 
• 922166-96-9 C₃₇H₆₁NO₁₁ 
• 922166-81-2 (E)-(3S,4S,7S,8R,9S,11S)-4-tert-butyldimethylsilyloxy-12-tert-butyldiphenylsilyloxy-3,8,9-trimethoxy-5,7,11-trimethyldodec-1,5-diene 

Downstream Products

• 70563-58-5 herbimycin A 

Relevant articles and documents

Total synthesis of herbimycin A

(Chemical Equation Presented) Hsp90 has recently emerged as a promising biological target for treatment of cancer. Herbimycin A and other members of the benzoquinoid ansamycin class of natural products are known to inhibit Hsp90 activity. The total synthesis of herbimycin A was achieved from the commercially available Roche ester 1 by using allylmetals to control the stereogenic centers at C6, C7, C10, C11, and C12 and a ring-closing metathesis to control the (Z)-double bond of the (E,Z)-dienic moiety.