922521-41-3Relevant academic research and scientific papers
Synthesis and insulin-sensitizing activity of (S)-2-ethoxy-3- phenylpropanoic acid derivatives
Cai, Xiao-Hua,Xie, Bing
, p. 1106 - 1109 (2007/10/03)
A series of (S)-2-ethoxy-3-phenylpropanoic acid derivatives were synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 1b (EC30 = 9.43 × 10-3 μmol/L), 1d (EC30 = 7.45 × 10-3 μmol/L), 1e (EC 30 = 6.22 × 10-3 μmol/L), and 1f (EC30 = 7.76 × 10-3 μmol/L) exhibited more potent insulin-sensitizing activity than rosiglitazone (EC30 = 2.06 × 10-2 μmol/L).
