101286-71-9

Basic information

• Product Name: Ethanol, 2-[(diphenylmethyl)methylamino]-
• CAS NO: 101286-71-9
• Molecular Formula: C16H19NO
• Molecular Weight: 241.333
• Mol File: 101286-71-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[(diphenylmethyl)methylamino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[(diphenylmethyl)methylamino]-(101286-71-9)
• EPA Substance Registry System: Ethanol, 2-[(diphenylmethyl)methylamino]-(101286-71-9)

Safety Data

• Hazardous Substances Data: 101286-71-9(Hazardous Substances Data)

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 776-74-9 Bromodiphenylmethane 
• 1630-62-2 3-methyl-2-phenyl-oxazolidine 
• 1078-58-6 diphenylzinc 
• 2051-90-3 Dichlorodiphenylmethane 
• 91-01-0 1,1-Diphenylmethanol 
• 90-99-3 diphenylchloromethane 
• 151696-82-1 2,2-Diphenyl-3-methyl-1,3-oxazolidine 
• 75-21-8 oxirane 
• 14683-47-7 N-(diphenylmethyl)methylamine 
• 98-80-6 phenylboronic acid 
• 100-52-7 benzaldehyde 

Downstream Products

• 134364-86-6 2-<4-<2-(N-benzhydryl-N-methylamino)ethylamino>phenyl>ethyl alcohol 
• 126202-87-7 2-<4--N-methylamino>phenyl>ethyl alcohol 
• 126202-65-1 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(4-{[2-(benzhydryl-methyl-amino)-ethyl]-methyl-amino}-phenyl)-ethyl] ester 5-methyl ester 
• 159050-55-2 2-(N-(Diphenylmethyl)-N-methylamino)ethyl 2-diazoacetoacetate 
• 632-50-8 1,1,2,2-tetraphenylethane 
• 922521-41-3 methanesulfonic acid 2-(benzhydryl-methyl-amino)-ethyl ester 
• 101784-11-6 1-(benzhydryl-methyl-amino)-2-chloroacetoxy-ethane; hydrochloride 
• 102600-03-3 1-(benzhydryl-methyl-amino)-2-(2-dimethylamino-ethoxy)-ethane 
• 101436-40-2 benzhydryl-(2-chloro-ethyl)-methyl-amine 

Relevant articles and documents

Atom-efficient transition-metal-free arylation ofN,O-acetals using diarylzinc reagents through Zn/Zn cooperativity

Exploiting the cooperative action of Lewis acid Zn(C6F5)2with diarylzinc reagents, the efficient arylation ofN,O-acetals to access diarylmethylamines is reported. Reactions take place under mild reaction conditions without the need for transtion-metal catalysis. Mechanistic investigations have revealed that Zn(C6F5)2not only acts as a Lewis acid activator, but also enables the regeneration of nucleophilic ZnAr2species, allowing a limiting 50 mol% to be employed.

Synthesis and insulin-sensitizing activity of (S)-2-ethoxy-3- phenylpropanoic acid derivatives

A series of (S)-2-ethoxy-3-phenylpropanoic acid derivatives were synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 1b (EC30 = 9.43 × 10-3 μmol/L), 1d (EC30 = 7.45 × 10-3 μmol/L), 1e (EC 30 = 6.22 × 10-3 μmol/L), and 1f (EC30 = 7.76 × 10-3 μmol/L) exhibited more potent insulin-sensitizing activity than rosiglitazone (EC30 = 2.06 × 10-2 μmol/L).

3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions comprising the same

3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of which is substituted with a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or the like, n is an integer of 1 to 3, R3and R4independently represents a hydrogen atom, a lower alkyl group, or the like, or a pharmaceutically acceptable salt thereof. Compounds (I) of the present invention have excellent MTP-inhibitory activity. Thus, these compounds not only inhibit formation of LDL that is a cause of arteriosclerotic diseases but also regulate TG, cholesterol, and lipoproteins such as LDL in the blood and regulate cellular lipids through regulation of MTP activity. They can also be used as a new type of preventive or therapeutic agents for hyperlipemia or arteriosclerotic diseases. Furthermore, they can be used as therapeutic or preventive agents for pancreatitis, obesity, hypercholesterolemia, and hypertriglyceridemia.