923973-12-0

Upstream product

• 1242415-74-2 C₁₆H₂₀INO₃ 
• 100-46-9 benzylamine 
• 155394-21-1 (S)-methyl 1-(2-Bromobenzoyl)pyrrolidine-2-carboxylate 
• 100-39-0 benzyl bromide 
• 24919-40-2 (S)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 

Relevant academic research and scientific papers

Syntheses of N10-substituted 7-arylpyrrolo[2,1-c]-[1,4]benzodiazepine-5,11- diones

Pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione and its 7-bromo derivative were alkylated at the N10 atom applying various methods. The resulting products were subjected to Suzuki-Miyaura reactions using a catalyst system consisting of Pd(Cl)2(PPh3)2 and sodium tert-butanolate in toluene. Results of an X-ray single crystal analysis are presented.

One-pot sequential Ti-/Cu-catalysis for tandem amidation/Ullmann-type cyclization: Synthesis of model benzodiazepine(di)ones promoted by microwave irradiation

The application of sequential Ti-/Cu-catalysis in the model one-pot synthesis of benzodiazepine(di)ones promoted by microwave irradiation demonstrates the expediency of dual catalysis in coupling-cyclization methods useful for diversity-oriented synthesis

Assembly of N-substituted pyrrolo[2, 1-c][1, 4]benzodiazepine-5, 11-diones via copper catalyzed aryl amination

Copper-catalyzed amination of N-heterocycle derived aryl iodides followed by intramolecular con- densative cyclization afforded N-substituted pyrrolo[2 1-c][1, 4]-benzodiazepine-5, 11-diones with good yields. By varying primary amines and substituents at aromatic ring of aryl iodides, a wide range of these heterocycles were assembled.