924-97-0

Usage

InChI:InChI=1/C7H12O3/c1-2-3-6(8)4-5-7(9)10/h2-5H2,1H3,(H,9,10)

Upstream product

• 108-30-5 succinic acid anhydride 
• 49770-81-2 methyl 4-oxoheptanoate 
• 68245-81-8 2-butyrylsuccinic acid dimethyl ester 
• 41117-77-5 2-butyrylsuccinic acid diethyl ester 
• 33018-76-7 2-oxo-5-propyl-2,3-dihydro-furan-3,4-dicarboxylic acid diethyl ester 
• 17615-01-9 1-(triphenyl-λ⁵-phosphanylidene)pentan-2-one 
• 96-32-2 bromoacetic acid methyl ester 
• 927-77-5 n-propylmagnesium bromide 
• 533-68-6 2-bromobutyric acid ethyl ester 
• 3283-25-8 3-Carboxy-3-heptensaeure 
• 106-94-5 propyl bromide 
• 201230-82-2 carbon monoxide 
• 557-20-0 diethylzinc 
• 137669-41-1 3-Ethoxycarbonyl-3-heptensaeure 

Downstream Products

• 105-21-5 4-propylbutanolide 
• 111-14-8 oenanthic acid 
• 120388-32-1 5-propyl-3-(o-chlorobenzyliden)furan-2-one 
• 1174409-44-9 C₁₄H₂₅NO₂ 
• 1427215-01-7 C₂₁H₂₀ClNO₄ 
• 1427215-16-4 2-(1-(4-chlorobenzoyl)-5-methoxy-2-propyl-1H-indol-3-yl)acetic acid 
• 22094-43-5 4-Hydroxy-heptansaeure-hydrazid 
• 77919-72-3 C₂₂H₂₆N₄O₂S 
• 77919-68-7 C₂₀H₂₁ClN₄OS 
• 77919-77-8 4-(4-Ethoxy-phenyl)-5-(2-propyl-1H-indol-3-ylmethyl)-4H-[1,2,4]triazole-3-thiol 
• 77919-69-8 C₂₁H₂₄N₄OS 
• 77919-70-1 C₂₁H₂₄N₄OS 
• 77919-76-7 5-(2-Propyl-1H-indol-3-ylmethyl)-4-m-tolyl-4H-[1,2,4]triazole-3-thiol 
• 77919-74-5 4-(4-Chloro-phenyl)-5-(2-propyl-1H-indol-3-ylmethyl)-4H-[1,2,4]triazole-3-thiol 

Relevant academic research and scientific papers

Acyl acid derivative and preparation method and medical application thereof

The invention relates to an acyl acid derivative as well as a preparation method and medical application thereof. Specifically, the invention relates to a compound represented by a general formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the same, and the invention also relates to a use thereof as an active ingredient in the prevention and/or treatment of muscle atrophy-related diseases, including myogenic muscle atrophy, disuse muscle atrophy, senile muscle atrophy, neurogenic muscle atrophy, and a use in the prevention and/or treatment of obesity, fatty liver, cardiovascular and cerebrovascular diseases, metabolic diseases, and anti-aging, wherein the definition of each group in the general formula (I) is the same as the definition in the specification.

Nickel promoted functionalization of CO2 to anhydrides and ketoacids

The reductive functionalization of carbon dioxide into high value organics was accomplished via the coupling with carbon monoxide and ethylene/propylene at a zerovalent nickel species bearing the 2-((di-t-butylphosphino)methyl)pyridine ligand (PN). An initial oxidative coupling between carbon dioxide, olefin, and (PN)Ni(1,5-cyclooctadiene) afforded five-membered nickelacycle lactone species, which were produced with regioselective 1,2-coupling in the case of propylene. The propylene derived nickelacycle lactone was isolated and characterized by X-ray diffraction. Addition of carbon monoxide, or a combination of carbon monoxide and diethyl zinc to the nickelacycle lactone complexes afforded cyclic anhydrides and 1,4-ketoacids, respectively, in moderate to high yields. The primary organometallic product of the transformation was zerovalent (PN)Ni(CO)2. This journal is

SUBSTITUTED AMINO-BENZIMIDAZOLES, MEDICAMENTS COMPRISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE

The present invention relates to substituted amino-benzimidazoles of general formula (1) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.

A simple synthesis of α-methyl-γ-keto acids

The reaction of the anion derived from α-marpholinonitriles with methyl acrylate in excess of NaH in DMF gives γ-keto acids in high yield. This process is highly convenient for the synthesis of various α-substituted-γ-keto acids, which can be easily converted to naturally occurring α-substituted -γ-lactones.

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.

Asymmetric hydrogenation method of a ketonic compound and derivative

The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1

A general and versatile synthesis of 4- and 5-oxoacids

The condensation of Grignard reagents with succinic or glutaric anhydrides in presence of a catalytic amount of CuI is a good way for the preparation of 4- or 5-oxoacids.

Intramolecular H-Transfer Reactions During the Decomposition of Alkylhydroperoxides in Hydrocarbons as the Solvents

Eight defined primary and secondary alkylhydroperoxides were decomposed in n-alkanes as the solvent, mostly in the presence of manganese stearate.In all cases the corresponding alcohols and carbonyl compounds were formed as the main products with yields of 60-90percent.Besides, difunctional products were formed by an intramolecular H-transfer in the alkoxy radicals corresponding to the starting hydroperoxides.Products possibly formed by an intramolecular H-transfer in the corresponding alkylperoxy radical could be found only in the case of 4-methyl-2-hydroperoxy pentane.The amount of products formed by intramolecular H-transfer depended on the nature of the C-H bond in δ-position to the original hydroperoxy group and lay between 4percent (primary C-H in the case of 4-hydroperoxy heptane) and 13percent (tertiary C-H in the case of 2-hydroperoxy-5-methyl hexane) with respect to the starting hydroperoxide.The amount of products formed by oxidative attack of the alkoxy and alkylperoxy radicals at the normal paraffins used as the solvents was unexpectedly low (always less than 10percent with respect to the starting hydroperoxide).An increment system is proposed for the calculation of 13C-nmr shifts in alkyl hydroperoxides.

An Efficient Approach to β-Oxoadipate Derivatives and γ-Oxo Acids by the Reformatsky Reaction of Ethyl α-Bromoalkanoates with Succinic Anhydride

Ethyl 2-bromoalkanoates react with zinc and succinic anhydride in dimethylformamide forming 2-substituted 1-ethyl hydrogen 3-oxoadipates (hexanedioates) isolable in a yield of 56 - 78percent.When subjected to decarboxylative saponification, they afford 4-oxoalkanoic acids in overall yields of 50 - 72percent