17615-01-9

Basic information

• Product Name: 1-(TRIPHENYL-LAMBDA5-PHOSPHANYLIDENE)-PENTAN-2-ONE
• Synonyms: 1-(TRIPHENYL-LAMBDA5-PHOSPHANYLIDENE)-PENTAN-2-ONE
• CAS NO: 17615-01-9
• Molecular Formula: C₂₃H₂₃OP
• Molecular Weight: 346.401881
• Mol File: 17615-01-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(TRIPHENYL-LAMBDA5-PHOSPHANYLIDENE)-PENTAN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TRIPHENYL-LAMBDA5-PHOSPHANYLIDENE)-PENTAN-2-ONE(17615-01-9)
• EPA Substance Registry System: 1-(TRIPHENYL-LAMBDA5-PHOSPHANYLIDENE)-PENTAN-2-ONE(17615-01-9)

Safety Data

• Hazardous Substances Data: 17615-01-9(Hazardous Substances Data)

Usage

Synonyms

TPP, Wittig reagent

Chemical compound

Yes

Usage

Organic synthesis

Physical state

Yellow solid

Solubility

Soluble in organic solvents

Reaction

Commonly used in the Wittig reaction

Wittig reaction purpose

Formation of carbon-carbon double bonds

Chemical class

Phosphorane

Central atom

Phosphorus

Covalent bonding

Central phosphorus atom bonded to three phenyl groups and an alkyl or aryl group

Laboratory use

Synthesis of complex organic molecules

Importance

Significant reagent in the field of organic chemistry

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 141-75-3 butyryl chloride 
• 16844-99-8 trimethylsilyl butyrate 
• 3739-97-7 (trimethylsilyl)methylenetriphenylphosphorane 
• 105-54-4 butanoic acid ethyl ester 
• 19493-09-5 Methylenetriphenylphosphorane 
• 3739-98-8 triphenyl(trimethylsilylmethyl)phosphonium iodide 
• 75066-53-4 N-Butyryl-2-(triphenylphosphoranyliden)acetanilid 
• 64448-06-2 (N-phenyliminovinylidene)triphenylphosphorane 
• 603-35-0 triphenylphosphine 
• 75-03-6 ethyl iodide 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 75066-55-6 3-Oxo-2-(triphenylphosphoranyliden)hexananilid 

Downstream Products

• 55210-66-7 1-(2-hydroxy-phenyl)-hex-1-en-3-one 
• 21014-26-6 ethyl 3-cyclopropaneprop-2-enoate 
• 143771-09-9 (R)-2-(4-Oxo-heptyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 142841-61-0 (2R,5R)-N-<(benzyloxy)carbonyl>-5-butyl-2-(4-oxoheptyl)pyrrolidine 
• 67217-85-0 (-)-indolizidine 223AB 
• 262589-89-9 1-phenylhepta-1,2-dien-4-one 
• 627-19-0 1-Pentyne 
• 162335-17-3 (2R,5S)-2-Butyl-5-((E)-4-oxo-hept-2-enyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 143771-08-8 (S)-2-((E)-4-Oxo-hept-2-enyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 924-97-0 4-oxo-heptanoic acid 

Relevant articles and documents

Carprost tromethamine related impurity levobutyl 15-ketone and preparation method thereof

The invention relates to the technical field of compounds and preparation thereof, in particular to a prostaglandin tromethamine related impurity levobutyl 15-ketone and a preparation method thereof.The method comprises the following steps that 1, in the presence of a fifth organic solvent, strong base is used for carrying out dehydrogenation reaction on methyl triphenyl phosphine halide, ethyl butyrate is added after the reaction is carried out for a certain period of time, and a reaction solution is obtained; continuously reacting for a certain time to obtain 1-triphenylphosphine- 2-pentanone; and (2) carrying out wittig reaction on the 1-triphenylphosphine- 2-pentanone obtained in the step (1) and a second organic solvent solution of benzoyl corey lactone aldehyde to obtain butyl-15 ketone. The method has the characteristics that the operation is simple and convenient, the safety is high, the yield and the purity of the obtained product are high under optimal conditions, the requirements for impurity research can be met, and the like.

Antitumour polycyclic acridines. Part 13. Synthesis of 2-substituted 7H-pyrido[4,3,2-kl]acridines by thermolysis of 9-(5-alkyltriazol-1-yl)acridines

Interaction of phosphoranylidene ketones with 9-azidoacridine in refluxing benzene affords 9-(5-substituted triazol-1-yl)acridines, which, on thermolysis in boiling diphenyl ether at 259 °C, yield 2-substituted 7H-pyrido[4,3,2-kl] acridines in high yields. These tetracyclic acridines are less potent inhibitors of human tumour cells in vitro than their pentacyclic analogues.

Synthesis and reactions of [1-(trialkylsilyl)alkylidene]triphenylphosphoranes

Alkylidenetriphenylphosphoranes 1 react with trialkyl halosilanes 2 to afford silylated alkylidenephosphoranes 5, which can be converted to acylated alkylidenephosphoranes 8 and 10 by trimethylsilyl carboxylates 6 or carboxylic anhydrides 10. Bis(acylalkylidenephosphoranes) 13-15 are available from 5 and bis(trimethylsilyl) dicarboxylates 12 or cyclic or polymeric anhydrides 16, 17.