92433-07-3Relevant articles and documents
Method for synthesizing bromfenac sodium
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Paragraph 0040; 0041, (2017/08/31)
The invention discloses a method for synthesizing bromfenac sodium. The method comprises the steps of (1) carrying out acetylation reaction on 2-amino-4'-bromo benzophenone as a raw material to obtain a formula III: N-(2-(4'-bromo benzoyl)phenyl)acetamide; (2) reacting the N-(2-(4'-bromo benzoyl)phenyl)acetamide in a formula IV with a halogen acetylation reagent to obtain a formula V: N-acetyl-N-(2-(4'-bromo benzoyl)phenyl)-2-haloacetamide; (3) carrying out friedel-crafts reaction on the N-acetyl-N-(2-(4'-bromo benzoyl)phenyl)-2-haloacetamide to obtain a formula IV: 1-acetyl-7-(4-bromo-benzoyl chloride) indoline-2-ketone; and (4) finally hydrolyzing the 1-acetyl-7-(4-bromo-benzoyl chloride) indoline-2-ketone to obtain a target product. The method is low in cost, reaction is easy to control, post-treatment is simple, the overall yield is high, the method is economical and environmentally friendly, and a novel method for synthesizing the bromfenac sodium is provided.
Activation of C-H Activation: The Beneficial Effect of Catalytic Amount of Triaryl Boranes on Palladium-Catalyzed C-H Activation
Tischler, Orsolya,Bokányi, Zsófia,Novák, Zoltán
supporting information, p. 741 - 746 (2016/03/25)
Herein we report a novel approach to the acceleration of palladium-catalyzed C-H activation reactions. We demonstrated that the utilization of electron-deficient triaryl boranes as Lewis acidic cocatalysts of palladium enables the directed cross dehydrogenative coupling of aldehydes and anilides under mild reaction conditions. Study of the kinetic profile of the transformation reveals a unique, unexpectedly long induction period of the transformation.
Palladium-catalyzed C-H bond acylation of acetanilides with benzylic alcohols under aqueous conditions
Luo, Feihua,Yang, Jun,Li, Zhengkai,Xiang, Haifeng,Zhou, Xiangge
, p. 2463 - 2469 (2015/04/22)
Palladium-catalyzed dehydrogenative coupling reactions between acetanilides and benzylic alcohols under aqueous conditions are reported. A wide range of benzophenone derivatives could be obtained in good to excellent yields up to 98 %. Mechanism studies showed that a bimetallic palladium cyclopalladated complex might be involved in the catalysis.
Merging Photoredox with Palladium Catalysis: Decarboxylative ortho-Acylation of Acetanilides with α-Oxocarboxylic Acids under Mild Reaction Conditions
Zhou, Chao,Li, Pinhua,Zhu, Xianjin,Wang, Lei
supporting information, p. 6198 - 6201 (2016/01/09)
A room temperature decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids has been developed via a novel Eosin Y with Pd dual catalytic system. This dual catalytic reaction shows a broad substrate scope and good functional group tolera
A one-pot process for palladium catalyzed direct C-H acylation of anilines in water using a removable ortho directing group
Szabo, Fruzsina,Simko, Daniel,Novak, Zoltan
, p. 3883 - 3886 (2014/01/06)
A new mild, practical method for the synthesis of aminobenzophenone derivatives through a three step one-pot reaction sequence involving acylation of anilines, palladium catalyzed cross-dehydrogenative coupling of the formed anilides and the hydrolytic cleavage is reported. The full reaction sequence was performed under aqueous conditions.
Mild palladium-catalyzed oxidative direct ortho-C-H acylation of anilides under aqueous conditions
Szabo, Fruzsina,Daru, Janos,Simko, Daniel,Nagy, Tibor Zs.,Stirling, Andras,Novak, Zoltan
supporting information, p. 685 - 691 (2013/04/10)
Palladium-catalyzed cross-dehydrogenative coupling between anilides and aromatic aldehydes was achieved under aqueous conditions. A wide variety of the desired benzophenone derivatives was isolated in good to excellent yield. The reaction rate acceleration effect of acid and detergent has been demonstrated. Mechanistic insight has been obtained from quantum chemical calculations. Copyright
Palladium-catalyzed direct ortho -acylation through an oxidative coupling of acetanilides with toluene derivatives
Yin, Zhangwei,Sun, Peipei
, p. 11339 - 11344 (2013/02/23)
A facile ortho-acylation of acetanilides by a Pd-catalyzed oxidative C-H activation was developed in which low toxic, stable, and commercially available toluene derivatives were first used as acylation reagents by a tandem reaction to form o-acylacetanili
Palladium-catalyzed ortho-acylation of acetanilides with aldehydes through direct Ci-H bond activation
Li, Chengliang,Wang, Lei,Li, Pinhua,Zhou, Wei
supporting information; experimental part, p. 10208 - 10212 (2011/10/31)
Easy access to o-acyl acetanilides: A new Pd-catalyzed ortho-acylation of acetanilides with both aromatic and aliphatic aldehydes has been developed based on a Ci-H activation process. In the presence of tert-butyl hydroperoxide (TBHP) as the ideal oxidant, this reaction provides an efficient access to ortho-acyl acetanilides in good yields (see scheme). Copyright
Palladium-catalyzed oxidative C-H bond acylation of acetanilides with benzylic alcohols
Yuan, Yu,Chen, Duanteng,Wang, Xiaowei
, p. 3373 - 3379 (2012/02/03)
An efficient and clean method to construct C-C bonds has been developed via the acylation reaction of acetanilides with benzylic alcohols using tert-butyl hydroperoxide (TBHP) as oxidant catalyzed by palladium acetate in the presence of triflic acid (TfOH). The acylation reactions exhibit excellent reactivities, and up to 95% yield of the corresponding aryl ketone could be obtained under the optimal conditions. Copyright
Room temperature palladium-catalyzed decarboxylative ortho -acylation of acetanilides with α-oxocarboxylic acids
Fang, Ping,Li, Mingzong,Ge, Haibo
scheme or table, p. 11898 - 11899 (2010/11/02)
A novel Pd-catalyzed decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids is realized at room temperature. This reaction provides efficient access to o-acyl acetanilides under mild conditions.
