92435-56-8

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Chlorophenyl)-2-(4-Methoxyphenyl)ethanone is used as a building block for the synthesis of various pharmaceuticals and fine chemicals due to its potential biological and pharmacological activities. It is valuable for research and development in the pharmaceutical industry.
Used in Organic Synthesis:
1-(4-Chlorophenyl)-2-(4-Methoxyphenyl)ethanone is used as a reagent in organic synthesis, contributing to the production of various chemicals.
Used in Chemical Production:
1-(4-Chlorophenyl)-2-(4-Methoxyphenyl)ethanone is used as an intermediate in the production of various chemicals, playing a crucial role in the synthesis of a wide range of compounds.

Upstream product

• 108-90-7 chlorobenzene 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 193486-29-2 1-(4-chlorophenyl)-3-(4-methoxyphenyl)-2,2-dimethyl-propane-1,3-dione 
• 97723-29-0 4-chloro-4'-methoxy-benzoin 
• 6343-93-7 2-(4-methoxyphenyl)acetamide 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 1041810-99-4 (Z)-3-chloro-3-(4-chlorophenyl)-2-(4-methoxyphenyl)propenal 
• 54945-17-4 1-(4-chlorophenyl)-2-(4-methoxyphenyl)-ethane-1,2-dione 
• 97723-29-0 4-chloro-4'-methoxy-benzoin 
• 13628-99-4 α-bromo-4-chloro-4'-methoxy-deoxybenzoin 

Relevant academic research and scientific papers

Lewis Acid Assisted Electrophilic Fluorine-Catalyzed Pinacol Rearrangement of Hydrobenzoin Substrates: One-Pot Synthesis of (±)-Latifine and (±)-Cherylline

A microwave-irradiated solvent-free pinacol rearrangement of hydrobenzoin substrates catalyzed by a combination of N-fluorobenzenesulfonimide and FeCl3·6H2O was developed. Its selectivity was first investigated by density functional theory (DFT) calculations. Then the functional group tolerance was examined by synthesizing a series of substrates designed based on the insight provided by the DFT calculations. The application of the methodology was demonstrated by the efficient one-pot synthesis of (±)-latifine and (±)-cherylline, both are 4-aryltetrahydroisoquinoline alkaloids isolated from Amaryllidacecae plants.

Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles

The aim of this study was to investigate 4,5-diaryl isoselenazoles as multiple target non-steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into the inflammatory processes via different mechanisms of action creating a new class of compounds

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.

Efficient synthesis of deoxybenzoins from chalcones

β-Ketoaldehydes derived from chalcone epoxides by Lewis acid-catalyzed rearrangement underwent smooth deformylation when refluxed in tetrahydrofuran (THF) in the presence of ethylenediamine, affording deoxybenzoins in excellent yields. The method is general and useful for the preparation of deoxybenzoins with a variety of substitution patterns. Copyright Taylor & Francis Group, LLC.

Behavior of benzoins and hydroxy ketones in acid media: I. Reaction of 1-aryl-2-(2,5-dimethylthiophen-3-yl)-2-hydroxyethanones with thiols in trifluoroacetic acid

Reactions of 1-aryl-2-(2,5-dimethylthiophen-3-yl)-2-hydroxyethanones with thiols in trifluoroacetic acid lead to formation of substituted 1-aryl-2-(2,5-dimethylthiophen-3-yl)-2-sulfanylethanones. 2005 Pleiades Publishing, Inc.

Clemmensen reduction. XII The synthesis and acidolysis of some diaryl-substituted cyclopropane-1,2-diols. The possible involvement of a cyclopropyl cation

The generation of a number of 1,2-diarylcyclopropane-1,2-diols is reported. Reaction of these in situ with acid gives, primarily, an α,β-unsaturated ketone in which the aryl substituent attached to the double bond is that which is best able to stabilize a benzylic cation. It is proposed that the reaction proceeds by O-protonation of the cyclopropane- 1,2-diol, followed by loss of water and opening of the resulting cyclopropyl cation and final deprotonation. Such initial O-protonation contrasts with the C-protonation normally observed in the acidolysis of cyclopropanols and other dialkyl- and alkylaryl-cyclopropane-1,2-diols.