97723-29-0

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 92435-56-8 1-(4-chlorophenyl)-2-(4-methoxyphenyl)ethanone 
• 6343-93-7 2-(4-methoxyphenyl)acetamide 
• 13628-99-4 α-bromo-4-chloro-4'-methoxy-deoxybenzoin 

Downstream Products

• 54945-17-4 1-(4-chlorophenyl)-2-(4-methoxyphenyl)-ethane-1,2-dione 
• 94880-51-0 2-<4-Chlor-anilino>-1-<4-chlor-phenyl>-2-<4-methoxy-phenyl>-aethanon-(1) 
• 88648-95-7 1-p-chlorophenyl-2-p-methoxyphenyl-2-chloroethanone 
• 92435-56-8 1-(4-chlorophenyl)-2-(4-methoxyphenyl)ethanone 
• 95697-43-1 2-<4-Chlor-anilino>-2-<4-chlor-phenyl>-1-<4-methoxy-phenyl>-aethanon-(1) 
• 464153-68-2 4-(4-chlorophenyl)-5-(4-methoxyphenyl)-1H-imidazole-2(3H)-thione 
• 1415020-23-3 5-(4-chlorophenyl)-4-(4-methoxyphenyl)-2-(methylthio)-1H-imidazole 

Relevant academic research and scientific papers

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors

A series of 4,5-diaryl-1H-imidazole-2(3H)-thione was synthesized and their inhibitory potency against soybean 15-lipoxygenase and free radical scavenging activities were determined. Compound 11 showed the best IC50 for 15-LOX inhibition (IC50 = 4.7 μM) and free radical scavenging activity (IC50 = 14 μM). Methylation of SH at C2 position of imidazole has dramatically decreased the 15-LOX inhibition and radical scavenging activity as it can be observed in the inactive compound 14 (IC50 >250 μM). Structure activity similarity (SAS) showed that the most important chemical modification in this series was methylation of SH group and Docking studies revealed a proper orientation for SH group towards Fe core of the 15-LOX active site. Therefore it was concluded that iron chelating could be a possible mechanism for enzyme inhibition in this series of compounds.