92471-86-8

Basic information

• Product Name: (R)-5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid
• Synonyms: (R)-5-Chloro Naproxen;(R)-5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid
• CAS NO: 92471-86-8
• Molecular Formula: C14H13ClO3
• Molecular Weight: 264.70422
• Product Categories: Aromatics;Chiral Reagents;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 92471-86-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 431.1±30.0 °C(Predicted)
• Appearance: /
• Density: 1.296±0.06 g/cm3(Predicted)
• PKA: 4.73±0.30(Predicted)
• CAS DataBase Reference: (R)-5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid(92471-86-8)
• EPA Substance Registry System: (R)-5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid(92471-86-8)

Safety Data

• Hazardous Substances Data: 92471-86-8(Hazardous Substances Data)

Usage

Uses

(R)-5-Chloro Naproxen is an impurity of (R)-Naproxen (N377510).

Upstream product

• 5111-65-9 2-Bromo-6-methoxynaphthalene 
• 93-04-9 2-Methoxynaphthalene 
• 103477-02-7 5-chloro-6-methoxy-α-methyl-2-naphthaleneacetic acid methyl ester 
• 76145-94-3 1-(6'-methoxy-2'-naphthyl)-2-chloro-1-propanone 
• 104483-12-7 α-chloro-1-(5-chloro-6-methoxy-2-naphthyl)propanone 
• 2700-47-2 6-methoxy-2-propionylnaphthalene 
• 36814-90-1 methyl 2-(5-chloro-6-methoxynaphthalen-2-yl)propanoate 
• 102770-50-3 (S)-2-chloro-1-(5'-chloro-6'-methoxy-2'-naphthyl)propan-1-one 
• 38046-82-1 6-methoxynaphthalen-2-ylmagnesium bromide 
• 13101-92-3 1-chloro-2-methoxynaphthalene 
• 121071-95-2 1-(5-Chloro-6-methoxy-naphthalen-2-yl)-1,1-dimethoxy-propan-2-ol 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 
• 102849-61-6 (S)-2-chloro-1-(6'-methoxy-2'-naphthyl)propan-1-one 
• 26159-35-3 (S)-naproxen methyl ester 

Relevant articles and documents

Efficient halogenation synthesis method of aryl halide

The invention discloses an efficient halogenation synthesis method of aryl halide. The method comprises the following step: in the presence of a catalyst (sulfoxide or oxynitride), a halogenation reagent and a solvent, carrying out a halogenation reaction on an aromatic ring compound to obtain the aryl halide. According to the present invention, in the presence of a catalyst (sulfoxide or nitrogenoxide), a halogenation reagent and a solvent, the aromatic ring is subjected to an efficient halogenation reaction, such that the very useful aryl halide can be obtained with high activity and high selectivity; and by adopting the method disclosed by the invention, aryl halides can be efficiently synthesized, and the method has a wide application prospect in actual production.

Asymmetric synthesis of iridoid derivatives using resolved 2-phenylindoline as a chiral auxiliary

An asymmetric synthetic route to cis,cis-nepetalactol (component of the sex pheromone for the hop aphid, Phorodon humuli) is presented. 2-Phenylindoline was resolved to provide a chiral auxiliary for the cycloaddition of oxocitral. The resolution was made by chromatographic separation of the diastereomers of the urea derivative made from 2-phenylindoline and with (R)-(+)-α- methylbenzyl isocyanate, followed by reductive cleavage of the isolated diasteromers using diborane. The cycloaddition of oxocitral using (S)-2-phenylindoline yielded an enantiopure product after chromatography. Hydrolysis of the cycloaddition adduct yielded gastrolactol (3). As gastrolactol is a versatile synthon for the synthesis of iridoids, the overall procedure provides a general asymmetric route to elaborated iridoids. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.

Carboxylic acid synthesis process

A process is described for preparing alpha-arylalkanoic acids, which comprises preparing and subsequently rearranging ketals of formula STR1 (in which Ar, R, R1, R2 and R4 have the meanings given in the description). The ketals of formula II are prepared from the corresponding alpha-hydroxyketals. The rearrangement reaction is conducted under mild conditions.