502763-33-9

Upstream product

• 1178893-45-2 3-(hydroxymethyl)-4,4-dimethyl-2-methylenecyclohexanol 
• 1178893-26-9 C₁₄H₂₂O₄ 
• 108-98-5 thiophenol 
• 166022-29-3 (S)-(+)-(2',2'-dimethyl-6'-methylene-1'-cyclohexyl)methanol 
• 882-33-7 diphenyldisulfane 
• 188540-03-6 Methanesulfonic acid (S)-2,2-dimethyl-6-methylene-cyclohexylmethyl ester 
• 472-19-5 (2,2-dimethyl-6-methylenecyclohexyl)methanol 

Downstream Products

• 782474-51-5 Toluene-4-sulfonic acid (1S,2S)-1-hydroxy-2-[2-((S)-5-methoxy-2,7-dimethyl-2H-chromen-2-yl)-ethyl]-3,3-dimethyl-cyclohexylmethyl ester 
• 924884-84-4 (S)-2,2-dimethyl-6-methylene-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]cyclohexane 
• 924884-90-2 (S)-2,2-dimethyl-1-[3'-(benzothiazole-2''-sulfanyl)butyl]-6-methylenecyclohexane 
• 502763-37-3 (2E,6E)-9-((1S)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene 
• 145398-68-1 luffarin-P 
• 618120-18-6 (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol 
• 22733-60-4 siccanin 
• 618120-15-3 (1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman 
• 502763-34-0 (S)-1-[1′-benzenesulfonyl]methyl-2,2-dimehtyl-6-methylenecyclohexane 
• 69903-57-7 (S)-(+)-(2E,6E)-9-(2,2-dimethyl-6-methylenencyclohexyl)-3,7-dimethyl-2,6-nonadien-1-ol 

Relevant academic research and scientific papers

An enantioselective biomimetic total synthesis of (-)-siccanin

A convergent asymmetric synthesis of the clinically important antifungal agent (-)-siccanin (1) mimics the proposed biosynthetic pathway. A Pd-catalyzed asymmetric allylic alkylation was used to establish the stereochemistry, and sequential radical proces

A general strategy for the stereoselective synthesis of the furanosesquiterpenes structurally related to pallescensins 1-2

Here, we describe a general stereoselective synthesis of the marine furanosesquiterpenes structurally related to pallescensins 1-2. The stereoisomeric forms of the pallescensin 1, pallescensin 2, and dihydropallescensin 2 were obtained in high chemical and isomeric purity, whereas isomicrocionin-3 was synthesized for the first time. The sesquiterpene framework was built up by means of the coupling of the C10 cyclogeranyl moiety with the C5 3-(methylene)furan moiety. The key steps of our synthetic procedure are the stereoselective synthesis of four cyclogeraniol isomers, their conversion into the corresponding cyclogeranylsulfonylbenzene derivatives, their alkylation with 3-(chloromethyl)furan, and the final reductive cleavage of the phenylsulfonyl functional group to afford the whole sesquiterpene framework. The enantioselective synthesis of the α-, 3,4-dehydro-γ- and γ-cyclogeraniol isomers was performed using both a lipase-mediated resolution procedure and different regioselective chemical transformations.

Preparation of (S)-γ-cyclogeraniol by lipase-catalyzed transesterification and synthesis of (+)-trixagol and (+)-luffarin-P

Lipase-catalyzed kinetic resolution of γ-cyclogeraniol by Candida antarctica lipase B yielded 23% of enantiomerically pure (S)-γ-cyclogeraniol. (+)-trixagol and (+)-luffarin-P were synthesized from the obtained (S)-γ-cyclogeraniol, and the absolute config

Biomimetic enantioselective total synthesis of (-)-siccanin via the Pd-catalyzed asymmetric allylic alkylation (AAA) and sequential radical cyclizations

(-)-Siccanin (1), a natural product possessing significant antifungal properties, was synthesized enantioselectively via a biomimetic route. This synthetic route features two sequential radical cyclizations: a Ti(III)-mediated radical cyclization of epoxy

Synthesis of (+)-trixagol and its enantiomer, the terpenoid side chain of (-)-agelasine E

The naturally occurring γ-cyclogeranylgeraniol called (+)-trixagol has been synthesised for the first time. Trixagol was readily available in five steps from (S)-2,2-dimethyl-6-methylene-1-cyclohexanemethanol. The enantiomer of trixagol, which equates to