92675-49-5

Upstream product

• 92675-50-8 6-chloro-2-methyl-4-phenethylpyrimidine 
• 100-52-7 benzaldehyde 
• 1432581-12-8 (1E)-1-(dimethylamino)-5-phenylpent-1-en-3-one 
• 124-42-5 acetamidine hydrochloride 
• 17071-29-3 ethyl 3-oxo-5-phenylpentanoate 
• 50324-33-9 2-methyl-4-phenethyl-6(1H)-pyrimidinone 
• 14331-54-5 2,4-dimethylpyrimidine 
• 92675-48-4 2-methyl-4(E)-styrylpyrimidine 

Relevant academic research and scientific papers

ANTIVIRAL AGENT

The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH ; R A is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like)

Studies on Pyrimidine Derivatives. XXXVI. Reaction of 6-Substituted 2,4-Dimethylpyrimidines with Benzaldehyde in the Presence of Zinc Chloride

The condensation of 2,4(2,6)-dimethylpyrimidines (7a-c), but not 6-methoxy-2,4-dimethylpyrimidine (7d), with benzaldehyde in the presence of zinc chloride occurred at the 4(6)-methyl group predominantly.In contrast, the reaction of 7d under the same condi