Bioorganic and Medicinal Chemistry Letters p. 3452 - 3456 (2011)
Update date:2022-09-26
Topics:
Soth, Michael
Abbot, Sarah
Abubakari, Allassan
Arora, Nidhi
Arzeno, Humberto
Billedeau, Roland
Dewdney, Nolan
Durkin, Kieran
Frauchiger, Sandra
Ghate, Manjiri
Goldstein, David M.
Hill, Ronald J.
Kuglstatter, Andreas
Li, Fujun
Loe, Brad
McCaleb, Kristen
McIntosh, Joel
Papp, Eva
Park, Jaehyeon
Stahl, Martin
Sung, Man-Ling
Suttman, Rebecca
Swinney, David C.
Weller, Paul
Wong, Brian
Zecic, Hasim
Gabriel, Tobias
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.
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Doi:10.1007/s00044-012-0392-4
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