929617-38-9

Usage

Uses

Used in Pharmaceutical Research and Development:
1H-Indazole-1-carboxylic acid, 5-bromo-6-nitro-, 1,1-dimethylethyl ester is used as a building block for the synthesis of biologically active molecules and pharmaceutical compounds. Its unique structure and functional groups make it a promising candidate for the development of new drugs.
Used in Chemical Research:
1H-Indazole-1-carboxylic acid, 5-bromo-6-nitro-, 1,1-dimethylethyl ester is used as a chemical reagent in different organic synthesis pathways. Its versatility and reactivity make it a valuable tool for researchers in the field of chemistry.
Used in Drug Development:
1H-Indazole-1-carboxylic acid, 5-bromo-6-nitro-, 1,1-dimethylethyl ester has the potential to be used in the development of new drugs. Its unique properties and reactivity can contribute to the discovery of novel therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 71785-49-4 5-bromo-6-nitro-1H-indazole 
• 13194-70-2 4-bromo-2-methylaniline hydrochloride 
• 71785-48-3 4-bromo-2-methyl-5-nitroaniline 

Downstream Products

• 929617-39-0 tert-butyl 5-bromo-6-amino-1H-indazole-1-carboxylate 

Relevant academic research and scientific papers

Tricyclic derivative inhibitor as well as preparation method and applications thereof

The invention relates to a tricyclic derivative inhibitor as well as a preparation method and applications thereof, in particular to a compound shown in a general formula (I) in the description, a preparation method of the compound, pharmaceutical composi

Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt

Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.