929617-39-0 Usage
Uses
Used in Pharmaceutical Industry:
1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER is used as a chemical intermediate for the synthesis of pharmaceutical compounds due to its unique structural features, which may contribute to the development of new drugs with specific therapeutic properties.
Used in Chemical Synthesis:
In the chemical synthesis industry, 1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER serves as a key building block for the creation of more complex organic molecules, potentially leading to novel materials and chemical products.
Used in Research and Development:
1H-INDAZOLE-1-CARBOXYLIC ACID,6-AMINO-5-BROMO-,1,1-DIMETHYLETHYL ESTER is utilized in research settings to study the biological activities of indazole derivatives, which may provide insights into their potential applications in medicine and other fields. This research could lead to the discovery of new therapeutic agents or chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 929617-39-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,9,6,1 and 7 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 929617-39:
(8*9)+(7*2)+(6*9)+(5*6)+(4*1)+(3*7)+(2*3)+(1*9)=210
210 % 10 = 0
So 929617-39-0 is a valid CAS Registry Number.
929617-39-0Relevant academic research and scientific papers
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt
Zhu, Gui-Dong,Gong, Jianchun,Gandhi, Viraj B.,Woods, Keith,Luo, Yan,Liu, Xuesong,Guan, Ran,Klinghofer, Vered,Johnson, Eric F.,Stoll, Vincent S.,Mamo, Mulugeta,Li, Qun,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 2441 - 2452 (2007/10/03)
Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.
