93-36-7

Usage

Uses

Used in Dye and Pigment Production:
7-amino-2-naphthol is used as a key intermediate in the production of dyes and pigments, particularly for azo dyes, due to its ability to form color compounds.
Used in Organic Synthesis:
In the field of organic synthesis, 7-amino-2-naphthol is used as a reagent for the preparation of various pharmaceuticals and agrochemicals, contributing to the development of new and effective products.
Used in Analytical Chemistry:
7-amino-2-naphthol is employed as a reagent in the spectrophotometric determination of metals, providing a method for accurate metal analysis in various applications.
Used in Pharmaceutical and Agrochemical Industries:
7-amino-2-naphthol is used as a building block in the synthesis of pharmaceuticals and agrochemicals, enhancing the development of new drugs and agricultural products.
Due to its diverse applications and importance in multiple industries, 7-amino-2-naphthol is a compound of significant interest to researchers and manufacturers.

InChI:InChI=1/C10H9NO/c11-9-3-1-7-2-4-10(12)6-8(7)5-9/h1-6,12H,11H2

Upstream product

• 582-17-2 2,7-Dihydroxynaphthalene 
• 613-76-3 2,7-diaminonaphthalene 
• 875-83-2 sodium 2-naphtholate 
• 135-19-3 β-naphthol 
• 7664-41-7 ammonia 
• 91-20-3 naphthalene 

Downstream Products

• 613-76-3 2,7-diaminonaphthalene 
• 41363-00-2 7-OH-AT 
• 851773-96-1 7-aminotetralin-2-ol 
• 889884-92-8 toluene-4-sulfonic acid-7-amino-napthalene-2-yl-ester 
• 873387-74-7 2-acetoxy-7-benzoylamino-naphthalene 
• 109091-25-0 N-7-(hydroxynaphthalen-2-yl)benzamide 
• 128542-48-3 2-iodo-7-methoxynaphthalene 
• 92287-46-2 2-amino-7-methoxynaphthalene 
• 2997-69-5 2-benzoylamino-7-benzoyloxy-naphthalene 
• 1361226-17-6 N⁽¹⁾-(4-butylphenyl)-N⁽²⁾-(7-hydroxynaphthalen-2-yl)phthalamide 

Relevant academic research and scientific papers

Altering Fundamental Trends in the Emission of Xanthene Dyes

Fluorescent small molecules enable researchers and clinicians to visualize biological events in living cells, tissues, and organs in real time. Herein, the focus is on the structure and properties of the relatively rare benzo[a]xanthenes that exhibit enhanced steric and electronic interactions due to their annulated structures. Three types of fluorophores were synthesized: (i) pH- and solvent-dependent seminaphthorhodafluors, (ii) pH- and solvent-independent seminaphthorhodafluors, and (iii) pH-independent but solvent-sensitive seminaphthorhodamines. The probes exhibited promising far-red to near-infrared (NIR) emission, large Stoke shifts, broad full width at half-maximum (fwhm), relatively high quantum yields, and utility in immunofluorescence staining. Deviation of the π-system from planarity due to changes in the fluorophore ionization state resulted in fluorescence properties that are atypical of common xanthene dyes.

Rhodium-catalyzed asymmetric hydrogenation of olefins with PhthalaPhos, a new class of chiral supramolecular ligands

A library of 19 binol-derived chiral monophosphites that contain a phthalic acid diamide group (Phthala- Phos) has been designed and synthesized in four steps. These new ligands were screened in the rhodium-catalyzed enantioselective hydrogenation of prochiral dehydroamino esters and enamides. Several members of the library showed excellent enantioselectivity with methyl 2-acetamido acrylate (6 ligands gave >97% ee), methyl (Z)-2- acetamido cinnamate (6 ligands gave >94% ee), and N-(1-phenylvinyl)acetamide (9 ligands gave >95% ee), whilst only a few representatives afforded high enantioselectivities for challenging and industrially relevant substrates N-(3,4-dihydronaphthalen-1- yl)-acetamide (96% ee in one case) and methyl (E)-2-(acetamidomethyl)-3- phenylacrylate (99% ee in one case). In most cases, the new ligands were more active and more stereoselective than their structurally related monodentate phosphites (which are devoid of functional groups that are capable of hydrogen-bonding interactions). Control experiments and kinetic studies were carried out that allowed us to demonstrate that hydrogen-bonding interactions involving the diamide group of the PhthalaPhos ligands strongly contribute to their outstanding catalytic properties. Computational studies carried out on a rhodium precatalyst and on a conceivable intermediate in the hydrogenation catalytic cycle shed some light on the role played by hydrogen bonding, which is likely to act in a substrate-orientation effect.

Inhibitors of checkpoint kinases

The instant invention provides for compounds which comprise fused imidazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.

Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition

The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification. and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.

BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS

This invention relates to bicyclic amide, carbamate or urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The bicyclic amide, carbamate or urea derivative of the present invention has vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

Method for preparing adduct of butadiene polymer or copolymer and α, β-ethylenically unsaturated dicarboxylic acid compound

In a method for preparing an adduct of (A) a butadiene lower polymer or butadiene lower copolymer and (B) a α,β-ethylenically unsaturated dicarboxylic acid compound, said method is characterized in that said (A) and (B) are caused to react in the presence of one or more compounds selected from (C) p-phenylenediamine derivatives, catechol derivatives, pyrogallol derivatives, N-nitrosamines, quinoline derivatives and naphthol derivatives, thus serious increase of the viscosity of said adduct in the addition reaction can be prevented.