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Upstream product

• 103-85-5 monophenylthiourea 
• 123-54-6 acetylacetone 
• 1694-29-7 3-chloropentane-2,4-dione 
• 62-53-3 aniline 
• 1333391-55-1 3-dimethylamino-1-[4-methyl-2-(methyl(phenyl)amino)thiazol-5-yl]propenone 
• 6685-76-3 phenylguanidinium hydrogencarbonate 

Relevant academic research and scientific papers

Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro

A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by 1H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549. Thiazolyl-pyrimidines were synthesized by the general pyrimidine condensation of Bredereck and their in-vitro anticancer activities were evaluated. Copyright

THIAZOLES AS FUNGICIDES

Use of compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and X, Y, Z are as defined in the description as fungicides. Compounds of the formula (Ia)