93098-10-3

Upstream product

• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 105-36-2 ethyl bromoacetate 
• 103-82-2 phenylacetic acid 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 101597-51-7 4-(4-methoxyphenyl)-4-oxo-3-phenylbutyric acid 
• 433330-76-8 6-(4-methoxy-phenyl)-5-phenyl-4,5-dihydro-2H-pyridazin-3-one 
• 225666-34-2 6-(4-Methoxyphenyl)-5-phenyl-2H-pyridazin-3-one 
• 388606-35-7 6-chloro-3-(4-methoxyphenyl)-4-phenylpyridazine 

Relevant academic research and scientific papers

Pyridizinone derivatives

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.

Mono- and di-substituted 5,6-diphenyl-3-alkylaminopyridazines active as ACAT inhibitors

A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.

An Unusual Reaction of a Phosphorane with Benzoins: Formation of 1,2-Dicarbonyl and 1,4-Dicarbonyl Compounds

Benzoins (1a-e) on reaction with carbethoxymethylenetriphenylphosphorane (2) furnish hydroxy esters (3a-e) and butenolides (4a and 4e) along with the unusual products, benzils (5a-e) and ketoesters (6a-e) as major product.