93098-64-7Relevant academic research and scientific papers
Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors
Lou, Jun,Yang, Xiaoyan,Rao, Zhigang,Qi, Wenwen,Li, Jinhui,Wang, Haiyu,Li, Yuxi,Li, Jinping,Wang, Zhiming,Hu, Xianming,Liu, Peng,Hong, Xuechuan
, p. 466 - 473 (2014/07/21)
A series of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives were prepared to evaluate their ability of inhibiting neuraminidase (NA) of influenza A virus. All the compounds were synthesized in good yields starting from aldehyde by using a suitable synthetic strategy, which showed moderate inhibitory activity against influenza A NA. Compound 6g exhibited the strongest inhibitory activity against influenza virus A NA (IC50 = 17.64 μM), which indicated pyrimidine ring could be used as a core structure to design novel influenza NA inhibitors.
SYNTHESIS OF NOVEL 5-ALKOXYCARBONYL-5,6-DIHYDROPYRIMIDIN-4(3H)-ONES FROM 3-SUBSTITUTED 2-ALKOXYCARBONYL-2-PROPENOATES AND AMIDINES
Cho, Hidetsura,Ueda, Masaru,Ohnaka, Yoshiko,Hayashimatsu, Mariko
, p. 1959 - 1963 (2007/10/02)
A cyclization of 3-substituted 2-alkoxycarbonyl-2-propenoates with acetamidine, benzamidine, guanidine, or 1,1-dimethylguanidine hydrochloride in the presence of 1-2 eq of metal alkoxide afforded novel 5-alkoxycarbonyl-5,6-dihydropyrimidin-4(3H)-ones in g
