932-28-5

Usage

Uses

Used in Chemical Industry:
Ethanone, 2-chloro-1-cyclopentyl(9CI) is used as a solvent for various chemical processes, facilitating the dissolution of other substances and enabling efficient reactions.
Used in Pharmaceutical Production:
Ethanone, 2-chloro-1-cyclopentyl(9CI) is utilized as an intermediate in the synthesis of pharmaceutical compounds, contributing to the development of new drugs and medications.
Used in Agrochemical Production:
In the agrochemical industry, Ethanone, 2-chloro-1-cyclopentyl(9CI) serves as a key component in the production of pesticides and other agricultural chemicals, helping to improve crop protection and yield.
Used in Specialty Chemicals Manufacturing:
Ethanone, 2-chloro-1-cyclopentyl(9CI) is employed in the manufacturing of specialty chemicals, which are used in various industries such as coatings, adhesives, and plastics, enhancing their properties and performance.

Upstream product

• 4524-93-0 Cyclopentanecarboxylic acid chloride 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 32916-51-1 cyclopentylmagnesium chloride 
• 33240-34-5 cyclopentylmagnesium bromide 
• 3400-45-1 cyclopentanecarboxylic acid 
• 35964-12-6 1-Cyclopentyl-2-diazo-1-ethanone 
• 186581-53-3 diazomethane 

Downstream Products

• 5623-75-6 1-cyclopentyl-1-methoxy-oxirane 
• 4630-83-5 methyl 1-methylcyclopentanecarboxylate 
• 5217-05-0 1-methylcyclopentanecarboxylic acid 
• 749927-62-6 1-Cyclopentyl-2-(4-methoxy-phenylsulfanyl)-ethanone 
• 749934-26-7 2-[4-(2-Cyclopentyl-2-oxo-ethoxy)-2-fluoro-phenyl]-2-methyl-propionitrile 

Relevant academic research and scientific papers

Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent "ene"-Reductases

α-Tertiary amines are a common motif in pharmaceutically important molecules but are challenging to prepare using asymmetric catalysis. Here, we demonstrate engineered flavin-dependent ‘ene'-reductases (EREDs) can catalyze radical additions into oximes to prepare this motif. Two different EREDs were evolved into competent catalysts for this transformation with high levels of stereoselectivity. Mechanistic studies indicate that the oxime contributes to the enzyme templated charge-transfer complex formed between the substrate and cofactor. These products can be further derivatized to prepare a variety of motifs, highlighting the versatility of ERED photoenzymatic catalysis for organic synthesis.

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

TRICYCLIC PIPERAZINE DERIVATIVE

Disclosed are compounds useful as inhibitors of Phosphodiesterase 1 (PDE1), compositions thereof, and methods of using the same.

PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

PROCESS FOR THE PREPARATION OF BENZOTRIAZEPINE DERIVATIVES

The present invention is directed to a novel process for the preparation of benzo[e][1,2,4]triazepin-2-one derivatives, useful in the preparation of gastrin and cholecystokinin receptor ligands.

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).

Potent and subtype-selective CCK-B/gastrin receptor antagonists: 2,4-dioxo-1,5-benzodiazepines with a plane of symmetry

A series of CCK-B/gastrin receptor antagonists, 2,4-dioxo-1,5-benzodiazepine derivatives with a plane of symmetry, were designed, synthesized, and evaluated for antagonistic activity. Structure-activity relationship studies revealed that carbonylmethyl groups at both N-1 and N-5 positions and hydrophilic groups, such as the carboxyl group on the benzene ring attached to the ureido group at the C-3 position, brought about potent affinity and subtype selectivity for CCK-B/gastrin receptors. Several compounds showed excellent in vivo inhibition of gastric acid secretion induced by pentagastrin in anesthetized rats.