93323-29-6

Basic information

• Product Name: 4-Quinolinamine, 2-(2-phenylethenyl)-
• CAS NO: 93323-29-6
• Molecular Formula: C17H14N2
• Molecular Weight: 246.312
• Mol File: 93323-29-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Quinolinamine, 2-(2-phenylethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinolinamine, 2-(2-phenylethenyl)-(93323-29-6)
• EPA Substance Registry System: 4-Quinolinamine, 2-(2-phenylethenyl)-(93323-29-6)

Safety Data

• Hazardous Substances Data: 93323-29-6(Hazardous Substances Data)

Upstream product

• 113798-28-0 4-chloro-2-[(1E)-2-phenylethenyl]quinoline 
• 422565-83-1 (E)-N-(2-styrylquinolin-4-yl)acetamide 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 6628-04-2 4-amino-2-methylquinoline 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold

A new class of quinoline derivatives, bearing amino chains at C-4 and a styryl group at C-2, were tested on Leishmania donovani promastigotes and axenic and intracellular Leishmania pifanoi amastigotes. The introduction of the C-4 substituent improves the activity, which is due to interference with the mitochondrial activity of the parasite and its concomitant bioenergetic collapse by ATP exhaustion. Some compounds show a promising antileishmanial profile, with low micromolar or submicromolar activity on promastigote and amastigote forms and a good selectivity index.