93334-81-7Relevant articles and documents
Cinnoline derivatives as human neutrophil elastase inhibitors
Giovannoni, Maria Paola,Schepetkin, Igor A.,Crocetti, Letizia,Ciciani, Giovanna,Cilibrizzi, Agostino,Guerrini, Gabriella,Khlebnikov, Andrei I.,Quinn, Mark T.,Vergelli, Claudia
, p. 628 - 639 (2016/05/09)
Compounds that can effectively inhibit the proteolytic activity of human neutrophil elastase (HNE) represent promising therapeutics for treatment of inflammatory diseases. We present here the synthesis, structure-activity relationship analysis, and biolog