18514-85-7

Basic information

• Product Name: 4(1H)-oxocinnoline 3-carboxylic acid
• Synonyms: 4(1H)-oxocinnoline 3-carboxylic acid;4-Oxo-1,4-dihydrocinnoline-3-carboxylic acid;4-oxo-1,4-dihydrocinnoline-3-carboxylic
• CAS NO: 18514-85-7
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.15554
• Mol File: 18514-85-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(1H)-oxocinnoline 3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-oxocinnoline 3-carboxylic acid(18514-85-7)
• EPA Substance Registry System: 4(1H)-oxocinnoline 3-carboxylic acid(18514-85-7)

Safety Data

• Hazardous Substances Data: 18514-85-7(Hazardous Substances Data)

Usage

General Description

4(1H)-oxocinnoline 3-carboxylic acid, also known as quinoline-3-carboxylic acid, is a chemical compound with the molecular formula C10H7NO3. It is a derivative of quinoline, a heterocyclic aromatic compound commonly used in organic synthesis and pharmaceuticals. 4(1H)-oxocinnoline 3-carboxylic acid contains a carboxylic acid group, which can participate in various biochemical processes. 4(1H)-oxocinnoline 3-carboxylic acid has been studied for its potential pharmacological properties, including its ability to act as an inhibitor of certain enzymes and receptors. Its unique chemical structure makes it a valuable target for further research and potential therapeutic applications.

Upstream product

• 40885-82-3 2-(phenylhydrazono)malonic acid 
• 1044741-83-4 C₁₃H₁₄N₂O₃ 
• 6134-59-4 diethyl 2-(phenylhydrazono)malonate 
• 142-04-1 aniline hydrochloride 
• 530-85-8 3-(2-nitrophenyl)-2-propynoic acid 
• 19288-90-5 2-(phenylhydrazono)-propanedioyl dichloride 

Downstream Products

• 854888-36-1 (6-nitro-cinnolin-4-yl)-phenyl-amine 
• 5265-43-0 1-Methyl-6-nitro-4-cinnolon 
• 7398-02-9 4-Methoxy-6-nitro-cinnolin 
• 68211-17-6 4-chloro-6-nitrocinnoline 
• 93334-81-7 1-Acetyl-4-cinnolon 
• 854897-28-2 6-amino-1H-cinnolin-4-one 
• 1556-22-5 1-methylcinnolin-4(1H)-one 
• 18514-84-6 4(1H)-cinnolon 

Relevant articles and documents

Novel synthesis of cinnolines and 1-aminoindolines via Cu-catalyzed intramolecular N-arylation of hydrazines and hydrazones prepared from 3-haloaryl-3-hydroxy-2-diazopropanoates

(Chemical Equation Presented) A new and facile access to cinnolines, dihydrocinnolines, and 1-aminoindolines was established by use of diazo functionalities. The hydrazines and hydrazones as cyclization precursors derived from 3-haloaryl-3-hydroxy-2-diazopropanoates, which are prepared by one-pot procedure utilizing phase-transfer catalysis, are successfully converted to the corresponding nitrogen heterocycle by Cu-catalyzed N-arylation. Furthermore, analysis of UV spectra proved that 4-oxo-3-carboxylates predominantly exist not as 4-hydroxycinnoline (enol form) but as cinnolone (keto form).

Solid phase synthesis of 6-acylamino-1-alkyl/aryl-4-oxo-1,4- dihydrocinnoline-3-carboxamides

6-Acylmino-1-alkyl/aryl-4-oxo-1,4-dihydrocinnoline-3-carboxamides were synthesized in parallel from 6-nitro-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid. The latter formed amides with amines bound to polystyrene-based resins via acid-labile linkers. N1 an